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TranscriptomicsInterleukin-27 priming of T cells controls Interleukin-17-production in trans via induction of Programmed cell death ligand 1
Interleukin (IL)-27 is a key immunosuppressive cytokine that counters T helper 17 (Th17) cell-mediated pathology. To identify mechanisms by which IL-27 might exert its immunosuppressive effect, we analyzed genes in T cells rapidly induced by IL-27. We found that IL-27 priming of naïve T cells upregu...
ORGANISM(S): Mus musculus 
2012-06-30 | E-GEOD-38375 | biostudies-arrayexpress
GenomicsInterleukin-27 is antiviral at the maternal-fetal interface
Interleukin-27 is antiviral at the maternal-fetal interface
PRJNA1268873 | ENA
TranscriptomicsInterleukin-27 is a potent inhibitor of cis HIV-1 replication in Monocyte-derived Dendritic Cells via a Type I Interferon-independent pathway
IL-27 treated DCs were shown to be highly potent inhibitors of cis HIV-1, particularly of CCR5 tropic strains. Microarray studies of IL-27 treated DCs showed no up-regulation of Type I (IFN) gene expression. Neutralization of the Type-I IFN receptor had no impact on the HIV inhibition. Lastly, IL-27...
ORGANISM(S): Homo sapiens 
2013-03-29 | E-GEOD-44732 | biostudies-arrayexpress
GenomicsTranscriptional profile of human monocyte-derived macrophages stimulated with Interleukin 27
Transcriptional profile of human monocyte-derived macrophages stimulated with Interleukin 27
PRJNA1095003 | ENA
GenomicsInterleukin-27 Gene Delivery Targeting IL-6Rα-Expressing Cells as a Stress Response Therapy
Interleukin-27 Gene Delivery Targeting IL-6Rα-Expressing Cells as a Stress Response Therapy
PRJNA1044108 | ENA
TranscriptomicsInterleukin-27 is antiviral at the maternal-fetal interface
Congenital viral infections can have severe consequences for pregnancy and fetal outcomes. Remarkably, the fetal-derived placenta serves as a robust barrier to infection through meticulous regulation by immune effectors and a diverse repertoire of cytokines. Yet, the regulatory roles of many cytokin...
ORGANISM(S): Homo sapiens 
2026-01-28 | GSE298278 | GEO
TranscriptomicsTranscriptional profile of human monocyte-derived macrophages stimulated with Interleukin 27
Interleukin 27 (IL-27) is a member of the IL-6 and/or IL-12 family that elicits both pro- and anti-inflammatory responses. Interferons (IFNs) are a family of cytokines that activate the JAK-STAT signaling pathway to induce an antiviral state in cells. Recent studies have reported that IL-27 also ind...
ORGANISM(S): Homo sapiens 
2024-04-15 | GSE262963 | GEO
GenomicsInterleukin 27 Protects From Gastric Atrophy and Metaplasia During Chronic Autoimmune Gastritis
Interleukin 27 Protects From Gastric Atrophy and Metaplasia During Chronic Autoimmune Gastritis
PRJNA1167764 | ENA
GenomicsInterleukin-27 remodels the bone marrow niche to suppress B-cell development and leukaemia progression in mouse models
Interleukin-27 remodels the bone marrow niche to suppress B-cell development and leukaemia progression in mouse models
PRJNA1428861 | ENA
TranscriptomicsInterleukin-27 priming of T cells controls Interleukin-17-production in trans via induction of Programmed cell death ligand 1
Interleukin (IL)-27 is a key immunosuppressive cytokine that counters T helper 17 (Th17) cell-mediated pathology. To identify mechanisms by which IL-27 might exert its immunosuppressive effect, we analyzed genes in T cells rapidly induced by IL-27. We found that IL-27 priming of naïve T cells upregu...
ORGANISM(S): Mus musculus 
2012-07-01 | GSE38375 | GEO
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