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TranscriptomicsMolecular defense mechanisms of Barrett's metaplasia estimated by an integrative genomics
Barrett's esophagus is characterized by the replacement of squamous epithelium with specialized intestinal metaplastic mucosa. The exact mechanisms of initiation and development of Barrett's metaplasia remain unknown, but a hypothesis of successful adaptation against noxious reflux components has be...
ORGANISM(S): Homo sapiens 
2012-03-08 | E-GEOD-36223 | biostudies-arrayexpress
GenomicsscATAC-seq analysis using gastric mucosa with intestinal metaplasia
scATAC-seq analysis using gastric mucosa with intestinal metaplasia
PRJNA913844 | ENA
ClinicalArtificial Intelligence-assisted Confocal Laser Endomicroscopy Identification of Intestinal Metaplasia Severity
Currently, the Correa cascade is a widely accepted model of gastric carcinogenesis. Intestinal metaplasia is a high risk factor for gastric cancer. According to Sydney criteria, mild intestinal metaplasia was not associated with gastric cancer, while moderate to severe intestinal metaplasia was stro...
2742066 | ecrin-mdr-crc
ClinicalIntestinal Metaplasia Cohort for Gastric Cancer Prediction
In this study, we aim to establish a prospective cohort of patients with endoscopically and histologically confirmed intestinal metaplasia, collect gastric mucosal tissue samples from this cohort, and follow the development of gastric cancer over time.
108653 | ecrin-mdr-crc
ClinicalThe Predictive Scores for Gastric Cancer in Gastric Intestinal Metaplasia (GIM) Patient: a Recommendation for Thai Population
The predictive scores for gastric cancer in gastric intestinal metaplasia(GIM) patient: a recommendation for Thai population. Objective: To evaluate major risk factors for gastric cancer in gastric intestinal metaplasia(GIM) patient in order to propose the appropriate recommendation for Thai people....
2117113 | ecrin-mdr-crc
GenomicsChIP-seq analysis of H3K27acethylation using gastric mucosa with intestinal metaplasia
ChIP-seq analysis of H3K27acethylation using gastric mucosa with intestinal metaplasia
PRJNA910982 | ENA
TranscriptomicsComparison of gene expression in the intestinal metaplasia in Cdx2/IL-1beta mice vs IL-1beta alone
Cdx2/IL-1beta mice have less intestinal metaplasia at the squamocolumnar junction thanIL-1beta mice alone. This study was to identify a mechanism for this effect by examining differences in gene expression patterns when Cdx2 is co-expressed. We dissected out intestinal metaplasia nodules from the sq...
ORGANISM(S): Mus musculus 
2016-08-01 | E-GEOD-60320 | biostudies-arrayexpress
GenomicsThe University of Hong Kong Intestinal Metaplasia Organoids Study
Background: Gastric intestinal metaplasia (IM) is a pre-cancerous stage spanning a morphological spectrum that is poorly represented by human cell line models. Objective: We aim to establish and characterize human IM cell models to better understand IM progression along the cancer spectrum. Design...
EGAS00001007899 | EGA
GenomicsExpression data from stomach biopsies with gastritis and intestinal metaplasia lesions
Expression data from stomach biopsies with gastritis and intestinal metaplasia lesions
PRJNA417555 | ENA
ClinicalGastric microbiota eradication for intestinal metaplasia
Interventions: After registration, a biopsy will be performed by upper gastrointestinal endoscopy (within 30 days of registration), and if the histological intestinal metaplasia score in the gastric fundus is 2 or higher, treatment will begin (within 30 days of upper gastrointestinal endoscopy). The...
102990 | ecrin-mdr-crc
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