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MetabolomicsMechanistic profiling of Bifemetstrobin against the tea anthracnose pathogen and candidate evaluation of an amine oxidase target
Tea anthracnose caused by Glomerella cingulata threatens yield and quality, while resistance to legacy fungicides highlights the need for new modes of action. We characterized the antifungal activity and mechanism of bifemetstrobin against G. cingulata by combining efficacy assays with cell biology ...
2026-04-24 | MTBLS14357 | MetaboLights
MetabolomicsMechanistic profiling of Bifemetstrobin against the tea anthracnose pathogen and candidate evaluation of an amine oxidase target

Tea anthracnose caused by Glomerella cingulata threatens yield and quality, while resistance to legacy fungicides highlights the need for new modes of action. We characterized the antifungal activity and mechanism of bifemetstrobin against G. cingulata by combining efficacy assays with cell ...

2026-03-13 | MTBLS13992 | MetaboLights
ProteomicsEnhancing Intracellular Concentration and Target Engagement of PROTACs with Reversible Covalent Chemistry
Current efforts in the proteolysis targeting chimera (PROTAC) field mostly focus on choosing the appropriate E3 ligase for a certain targeted protein, improving the binding affinities towards the target protein and the E3 ligase, and optimizing the PROTAC linker. However, it is well known that due t...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2020-02-04 | MSV000084902 | MassIVE
ProteomicsA probe-based target engagement assay for kinases in live cells
Protein kinases are an important class of drug targets due to their crucial roles in almost every aspect of cellular function, such as cell growth, metabolism, proliferation, differentiation, migration, effector functions and cell death. Starting from the previously described covalent promiscuous ki...
ORGANISM(S): Homo sapiens (Human) 
2025-04-07 | PXD047949 | Pride
Cellular target engagement Jurkat cells Lc-ms/ms 
ProteomicsA BRET Biosensor for Measuring Uncompetitive Engagement of PRMT5 Complexes in Cells
Protein arginine methyl transferase 5 (PRMT5) plays a global role in cell physiology and is an established therapeutic target in cancer. In approximately 10-15% of human cancers, deletion of the methylthioadenosine phosphorylase (MTAP) gene results in accumulation of methylthioadenosine (MTA), expos...
ORGANISM(S): Homo sapiens (Human) 
2025-12-08 | PXD028138 | Pride
Nanobret - chemical proteomics – cell-based assay – sam – target engagement – thermal profiling 
UnknownEnhancing intracellular accumulation and target engagement of PROTACs with reversible covalent chemistry.
Not available
S-EPMC7450057 | biostudies-literature
UnknownSmall Molecule Tools to Study Cellular Target Engagement for the Intracellular Allosteric Binding Site of GPCRs.
Not available
S-EPMC10100284 | biostudies-literature
UnknownFluorescent Ligands Enable Target Engagement Studies for the Intracellular Allosteric Binding Site of the Chemokine Receptor CXCR2.
Not available
S-EPMC10388362 | biostudies-literature
UnknownPrediction of intracellular exposure bridges the gap between target- and cell-based drug discovery.
Not available
S-EPMC5544291 | biostudies-literature
UnknownQuantitating drug-target engagement in single cells in vitro and in vivo.
Not available
S-EPMC5630128 | biostudies-literature
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