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TranscriptomicsINTERLEUKIN 15-DEPENDENT T CELL-LIKE INNATE INTRAEPITHELIAL LYMPHOCYTES DEVELOP IN THE INTESTINE AND TRANSFORM INTO LYMPHOMAS IN CELIAC DISEASE
The nature of gut intraepithelial lymphocytes lacking antigen receptors remains controversial. Herein we showed that, in humans and in mice, innate intestinal intraepithelial lymphocytes expressing intracellular CD3 (iCD3+ innate IELs) differentiate along an Id2 transcription factor (TF)-independent...
ORGANISM(S): Homo sapiens 
2016-11-23 | E-MTAB-4960 | biostudies-arrayexpress
TranscriptomicsExpression data from mouse small intestinal γδ intraepithelial lymphocytes
The mammalian gastrointestinal tract harbors thousands of bacterial species that include symbionts as well as potential pathogens. The immune responses that limit access of these bacteria to underlying tissue remain poorly defined. In this study, we used microarrays to uncover the transcriptional re...
ORGANISM(S): Mus musculus 
2011-04-06 | E-GEOD-28437 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse small intestine intraepithelial lymphocytes (IEL) vs. TCR ab+ CD8b+ and TCR gd+ cells
Mouse small intestine intraepithelial lymphocytes (IEL) that express a ab TCR and CD8aa homodimers are an enigmatic T cell subset, as their specificity and in vivo function remain to be defined. To gain insight into the nature of these cells, we performed global gene expression profiling using micr...
ORGANISM(S): Mus musculus 
2008-06-13 | E-GEOD-5355 | biostudies-arrayexpress
TranscriptomicsDisruption of PPARg signaling results in mouse prostatic intraepithelial neoplasia (mPIN) involving active autophagy
Peroxisome proliferator-activated receptor-gamma (PPARg) regulates the interface between cellular lipid metabolism, redox status and organelle differentiation. Following conditional prostatic epithelial knockout of PPARg in mice we observed focal hyperplasia of the epithelium which developed to mous...
ORGANISM(S): Mus musculus 
2010-05-18 | E-GEOD-13867 | biostudies-arrayexpress
GenomicsIntraepithelial T cells in intestine segments [I30]
Intraepithelial T cells in intestine segments [I30]
PRJNA1530575 | ENA
ProteomicsSingle-cell transcriptional profiling identifies a spectrum of unconventional intraepithelial T lineage cells in human cord blood
Conventional CD4 and CD8 single positive T cell lineages constitute the main differentiation pathway in the thymus. In human thymus, a minor TCRαβ differentiation pathway diverges from the early double positive stage, consisting of CD10+ PD-1+ cells. These cells are phenotypically and functionally s...
ORGANISM(S): Homo sapiens (Human) 
2023-02-10 | PXD033392 | Pride
Agonist-selection T cell lineages Shotgun proteomics Q exactive hf Human Intraepithelial t cells Cord blood Label-free Thymus 
GenomicsNewly recruited intraepithelial Ly6A+CCR9+CD4+ T cells protect against enteric viral infection
Newly recruited intraepithelial Ly6A+CCR9+CD4+ T cells protect against enteric viral infection
PRJNA804864 | ENA
TranscriptomicsMevalonate pathway antagonist inhibits proliferation of serous tubal intraepithelial carcinoma and ovarian carcinoma in mouse models.
Statins are among the most frequently prescribed drugs because of their efficacy and low toxicity in treating hypercholesterolemia. Recently, statins have been reported to inhibit the proliferative activity of cancer cells, especially those with *TP53* mutations. Since *TP53* mutations occur in ...
ORGANISM(S): Homo sapiens 
2015-11-04 | E-GEOD-68986 | biostudies-arrayexpress
TranscriptomicsSmall intestine intraepithelial CD4+ T cells after Toxoplasma gondii infection
Retention of lymphocytes in the intestinal mucosa requires specialized chemokine receptors and adhesion molecules. Here we find that both CD4+CD8+ and CD4+T cells in the intestinal epithelium, as well as CD8+T cells in the intestinal mucosa and mesenteric lymph nodes, express the cell adhesion molec...
ORGANISM(S): Mus musculus 
2014-02-15 | E-GEOD-55067 | biostudies-arrayexpress
GenomicsSingle-cell T-cell receptor sequencing of intraepithelial CD8+ αβ T-cells in celiac disease
Single-cell paired TCR sequencing of intraepithelial CD8+ αβ T-cells in gluten-free diet treated and untreated celiac disease patients and in controls. (Paired end, amplicon sequencing).
EGAS00001004989 | EGA
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