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MetabolomicsMyocardial-intrinsic defects underlie an Rbfox-mediated zebrafish model of hypoplastic left heart syndrome
Hypoplastic left heart syndrome (HLHS) is characterized by underdevelopment of left sided structures including the ventricle, valves, and aorta1. Although the mechanisms of disease pathogenesis remain elusive due to a paucity of candidate genes and animal models, prevailing paradigm suggests that HL...
2022-07-12 | MTBLS4176 | MetaboLights
TranscriptomicsHyper-excitability of Neurons generated from Patients with Bipolar Disorder
Bipolar Disorder (BD) is a complex neuropsychiatric disorder that is characterized by intermittent episodes of mania and depression and, without treatment, 15% of patients commit suicide1. Hence, among all diseases, BD has been ranked by the WHO as a top disorder of morbidity and lost productivity2....
ORGANISM(S): Homo sapiens 
2015-10-30 | E-GEOD-58933 | biostudies-arrayexpress
TranscriptomicsDistinct molecular signatures of mild extrinsic and intrinsic atopic dermatitis
Atopic dermatitis (AD) is a common inflammatory skin disease with underlying defects in epidermal function and immune responses. The goal of this study was to investigate differences in gene expression in lesional skin from patients with mild extrinsic or intrinsic AD compared to skin from healthy c...
ORGANISM(S): Homo sapiens 
2016-03-08 | E-GEOD-75890 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human monozygotic twins discordant for bipolar disorder
To identify genes dysregulated in bipolar disorder (BD1) we carried out global gene expression profiling using whole-genome microarrays. To minimize genetic variation in gene expression levels between cases and controls we compared expression profiles in lymphoblastoid cell lines from monozygotic tw...
ORGANISM(S): Homo sapiens 
2008-06-15 | E-GEOD-7036 | biostudies-arrayexpress
TranscriptomicsMicroarray profiling of monocytic differentiaion reveals miRNA-mRNA intrinsic correlation
This SuperSeries is composed of the following subset Series: GSE26376: Microarray profiling of monocytic differentiaion reveals miRNA-mRNA intrinsic correlation (miRNA) GSE26377: Microarray profiling of monocytic differentiaion reveals miRNA-mRNA intrinsic correlation (gene expression) Refer to indi...
ORGANISM(S): Homo sapiens 
2012-02-02 | E-GEOD-26379 | biostudies-arrayexpress
UnknownUnreported intrinsic disorder in proteins: Disorder emergency room.
Not available
S-EPMC5314879 | biostudies-literature
TranscriptomicsAffymetrix SNP array data for Diffuse Intrinsic Pontine Glioma
Diffuse intrinsic pontine glioma (DIPG) is one of the most devastating of paediatric malignancies and one for which no effective therapy exists. A major contributor to the failure of therapeutic trials is the assumption that biologic properties of brainstem tumours in children are identical to cereb...
ORGANISM(S): Homo sapiens 
2010-06-16 | E-GEOD-18828 | biostudies-arrayexpress
TranscriptomicsExpression profiling of skin fibroblast, iPSC, iPSC-derived neural progenitors, and iPSC-derived neurons from Autism Spectrum Disorder male patients and their unaffected normal male siblings
Autism spectrum disorder (ASD) is an early onset neurodevelopmental disorder, which is characterized by disturbances of brain function and behavioral deficits in core areas of impaired reciprocal socialization, impairment in communication skills, and repetitive or restrictive interests and behaviors...
ORGANISM(S): Homo sapiens 
2016-07-01 | E-GEOD-65106 | biostudies-arrayexpress
ProteomicsCell cycle phosphorylation dynamics in vivo reveals switch-like control of intrinsic disorder
Switch-like cyclin-dependent kinase (CDK)-1 activation is thought to underlie the abruptness of mitotic onset, but how CDKs can simultaneously phosphorylate many diverse substrates is unknown, and direct evidence for such phosphorylation dynamics in vivo is lacking. Here, we analysed protein phospho...
ORGANISM(S): Xenopus Laevis 
PXD026088 | panorama
UnknownEnrichment patterns of intrinsic disorder in proteins.
Not available
S-EPMC9842814 | biostudies-literature
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