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MetabolomicsGenome-wide mapping of genetic suppression events in Streptococcus pneumoniae
Historically, suppressor analysis has been a powerful tool for uncovering the functions of essential genes. In this study, we report Sup-seq, a transposon-sequencing technique with random DNA barcodes that enables genome-wide detection of genetic suppression. When applied to seven essential genes in...
2026-09-01 | MTBLS15113 | MetaboLights
MetabolomicsThe lipid-metabolism enzyme ECI2 reduces neutrophil extracellular traps formation for colorectal cancer suppression
Abnormalities in ether lipid metabolism as well as the formation of neutrophil extracellular traps have recently been recognized as detrimental factors affecting tumorigenesis and progression. However, the role of abnormal ether lipid metabolism in colorectal cancer (CRC) evolution has not been repo...
2024-10-01 | MTBLS10323 | MetaboLights
MetabolomicsBrown-fat-mediated tumour suppression by cold-altered global metabolism

Glucose uptake is essential for cancer glycolysis and is involved in non-shivering thermogenesis of adipose tissues. Most cancers use glycolysis to harness energy for their infinite growth, invasion and metastasis. Activation of thermogenic metabolism in brown adipose tissue (BAT) by cold an...

2022-08-12 | MTBLS4856 | MetaboLights
MetabolomicsAggressive breast cancers secrete heme metabolites to alter macrophage immune suppression and function
The heme catabolism pathway is often elevated in aggressive cancers; however, the impact of this pathway and some of its byproducts on the tumor microenvironment remain largely unknown. In human breast cancers, tumor expression of the heme catabolizing enzyme heme oxygenase-1 (HO-1/HMOX1) is positiv...
2026-04-24 | MTBLS14278 | MetaboLights
MetabolomicsEcology-guided Bacillus SynCom from a rice–duckweed core reveals division of labor for concurrent growth promotion and sheath blight suppression

Ecologically derived synthetic communities can provide robust plant benefits, yet generalizable rules for assembling multifunctional consortia remain limited. We hypothesized that a “top-down” community assembled from an ecological core would yield complementary functions and resilience superior ...

2025-09-22 | MTBLS13022 | MetaboLights
MetabolomicsMulti-omics profiling identifies MAPK signaling suppression associated with tetracycline-induced root toxicity in soybean
Tetracycline (TC), a widely used veterinary antibiotic, is a pervasive emerging contaminant threatening crop production. Here, we employed integrated physiological, metabolomic, and transcriptomic analyses to decipher the response of soybean (Glycine max L.) to TC. While seed germination was unaffec...
2026-09-07 | MTBLS15077 | MetaboLights
MetabolomicsMulti-omics integration reveals Yu-Xue-Bi tablets attenuate rheumatoid arthritis via metabolic reprogramming-mediated Piezo1 suppression

As a systemic chronic inflammatory disease, Rheumatoid arthritis (RA) is characterized by progressive inflammation, bone and cartilage destruction, leading to significant disability, reduced lifespan, and increased mortality. The clinical use of conventional medications including nonsteroidal ant...

2026-01-24 | MTBLS13760 | MetaboLights
MetabolomicsGut Microbiota Contributes to Heat Tolerance Through Metabolic Remodeling and Suppression of Thermogenesis in Chickens
Background The gut microbiota is increasingly recognized as a key regulator of host metabolic adaptation to environmental challenges. However, whether breed-specific gut microbiota contributes to variation in heat tolerance among poultry breeds remains unclear. This study used Cyan-shank partridge c...
2026-06-18 | MTBLS14785 | MetaboLights
MetabolomicsImpact of genetic suppression (shRNA) of ALDH1A1 expression in human colon cancer cell line (COLO320)
Not available
ORGANISM(S): Homo sapiens 
ST001093 | MetabolomicsWorkbench
MetabolomicsQijiao Shengbai capsule ameliorates ulcerative colitis in mice by modulating gut microbiota and protecting the intestinal barrier, associated with suppression of the TLR4/MyD88/NF-κB Pathway

Background: Qijiao Shengbai capsule (QJSB) is a classic traditional Chinese compound formulation composed of seven herbal ingredients, primarily used clinically to treat leukopenia. Individual herbs and their active components within QJSB demonstrate favorable efficacy against ulcerative colitis ...

2026-09-08 | MTBLS14943 | MetaboLights
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