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UnknownIdentification of a Drug Targeting an Intrinsically Disordered Protein Involved in Pancreatic Adenocarcinoma.
Intrinsically disordered proteins (IDPs) are prevalent in eukaryotes, performing signaling and regulatory functions. Often associated with human diseases, they constitute drug-development targets. NUPR1 is a multifunctional IDP, over-expressed and involved in pancreatic ductal adenocarcinoma (PDAC) ...
S-EPMC5213423 | biostudies-literature
TranscriptomicsTranscriptome Analysis Predicts Clinical Outcome and Sensitivity to Anticancer Drugs of patients with a Pancreatic Adenocarcinoma
A major impediment to the effective treatment of patients with PDAC (Pancreatic Ductal Adenocarcinoma) is the molecular heterogeneity of the disease, which is reflected in an equally diverse pattern of clinical responses to therapy. We developed an efficient strategy in which PDAC samples from 17 co...
ORGANISM(S): Homo sapiens 
2015-04-09 | E-GEOD-55513 | biostudies-arrayexpress
TranscriptomicsGenome profiling of pancreatic adenocarcinoma
Pancreatic adenocarcinoma is one of the most aggressive human cancers and displays many different chromosomal abnormalities and mutations. By using 244K high-resolution array-comparative genomic hybridization (aCGH) we studied the genome alterations of 39 fine-needle aspirations from pancreatic aden...
ORGANISM(S): Homo sapiens 
2011-12-31 | E-MTAB-570 | biostudies-arrayexpress
UnknownComplete Regression of Advanced Pancreatic Ductal Adenocarcinomas upon Combined Inhibition of EGFR and C-RAF.
Five-year survival for pancreatic ductal adenocarcinoma (PDAC) patients remains below 7% due to the lack of effective treatments. Here, we report that combined ablation of EGFR and c-RAF expression results in complete regression of a significant percentage of PDAC tumors driven by Kras/Trp53 mutatio...
S-EPMC10132447 | biostudies-literature
UnknownKetogenic HMG-CoA lyase and its product β-hydroxybutyrate promote pancreatic cancer progression
Pancreatic ductal adenocarcinoma (PDA) tumor cells are deprived of oxygen and nutrients and therefore must adapt their metabolism to ensure proliferation. In some physiological states, cells rely on ketone bodies to satisfy their metabolic needs, especially during nutrient stress. Here, we show that...
S-SCDT-EMBOJ-2021-110466 | biostudies-other
UnknownGuidelines for the use and interpretation of assays for monitoring autophagy (3rd edition).
Not available
S-EPMC4835977 | biostudies-literature
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