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MetabolomicsMetabolomics of aged iPSC
Not available
ORGANISM(S): Mus musculus 
ST000554 | MetabolomicsWorkbench
TranscriptomicsExpression profiling of skin fibroblast, iPSC, iPSC-derived neural progenitors, and iPSC-derived neurons from Autism Spectrum Disorder male patients and their unaffected normal male siblings
Autism spectrum disorder (ASD) is an early onset neurodevelopmental disorder, which is characterized by disturbances of brain function and behavioral deficits in core areas of impaired reciprocal socialization, impairment in communication skills, and repetitive or restrictive interests and behaviors...
ORGANISM(S): Homo sapiens 
2016-07-01 | E-GEOD-65106 | biostudies-arrayexpress
MetabolomicsUntargeted Mass Spectrometry Metabolomic Profiles of iPSC-derived Dopaminergic Neurons from Clinically Discordant Brothers with Identical PRKN Deletions
Not available
ORGANISM(S): Homo sapiens 
ST001957 | MetabolomicsWorkbench
TranscriptomicsGenetic variability exceeds cell-type memory and determines iPSCs differentiation potential-implications for biobanking
Summary To address the issue of retention of somatic cell memory in iPSCs we compared gene expressions of genetically matched human iPSCs derived from fibroblasts and blood. We were using the all-in-one type footprint free SeVdp-iPS system, for generation of uniform iPSC lines Our results show that...
ORGANISM(S): Homo sapiens 
2016-01-07 | E-MTAB-3825 | biostudies-arrayexpress
TranscriptomicsExpression data from of HD-iPSC and CON-iPSC neuron derivatives
Compared the global gene expression profiles of HD- and CON-iPSC-derived neurons We used microarrays to detail the global programme of gene expression for comparing the global gene expression profiles of HD- and CON-iPSC-derived neurons and facilitating studies of medium spiny neurons (MSN)-degenera...
ORGANISM(S): Homo sapiens 
2015-09-02 | E-GEOD-59051 | biostudies-arrayexpress
TranscriptomicsHistone Variant H2A.X Plays Novel Roles in Cell Lineage Commitment and Genomic Stability in ESC and iPSC
Herein, we demonstrated that the cell lineage commitment is unexpectedly regulated by the novel functions of H2A.X, a histone variant which was only well-known for its role in genome integrity maintenance previously. Surprisingly, only in ESCs but not differentiated cells, H2A.X is specifically targ...
ORGANISM(S): Mus musculus 
2014-09-07 | E-GEOD-49147 | biostudies-arrayexpress
TranscriptomicsMolecular and functional characterization of FD-iPSC derived neural crest precursor cells
Global gene expression analysis of FD-iPSC and deribved neural crest cells Here we report the derivation of patient specific Familial Dysautonomia-iPSCs and their directed differentiation into multiple cell types capable of modeling the tissue specific splicing defect in vitro. Undifferentiated hES...
ORGANISM(S): Homo sapiens 
2009-08-31 | E-GEOD-17043 | biostudies-arrayexpress
TranscriptomicsHuman iPSC-based Modeling of Late-Onset Disease using Progerin-induced Aging
Reprogramming somatic cells to induced pluripotent stem cells (iPSCs) sets their identity back to an embryonic age. This presents a fundamental hurdle for modeling late-onset disorders using iPSC-derived cells. We therefore developed a strategy to induce age-like features in multiple iPSC-derived li...
ORGANISM(S): Homo sapiens 
2014-01-23 | E-GEOD-52431 | biostudies-arrayexpress
ProteomicsDevelopment and Comparative Evaluation of Endolysosomal Proximity Labeling-based Proteomic Methods in Human iPSC-derived Neurons
Proximity-based in situ labeling techniques offer a unique way to capture both stable and transient protein-protein and protein-organelle interactions. Combining this technology with mass spectrometry (MS)-based proteomics allows us to obtain snapshots of molecular microenvironments with nanometer r...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2020-10-10 | MSV000086260 | MassIVE
TranscriptomicsHuman iPSC-Derived Cerebellar Neurons from a Patient with Ataxia-Telangiectasia Reveal Disrupted Gene Regulatory Networks
Control (CRL2429 C11) and A-T (MC3/AT30) iPSC were differentiated according to Erceg et al to generate cerebellar precursors Examination of changes in gene expression after a 34 day differentiation protocol in control and A-T iPSC
ORGANISM(S): Homo sapiens 
2017-10-02 | E-GEOD-75852 | biostudies-arrayexpress
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