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ProteomicsAltered mRNA transport and local translation in iNeurons with RNA binding protein knockdown
Neurons rely on mRNA transport and local translation to facilitate rapid protein synthesis in processes far from the cell body. These processes allow precise spatial and temporal control of translation and are mediated by RNA binding proteins (RBPs), including those known to be associated with neuro...
ORGANISM(S): Homo sapiens (Human) 
2025-07-30 | PXD054548 | Pride
Human Ipsc derived ineurons 
UnknownA HaloTag-4R-Tau Pulse-Chase Sensor Reveals Neddylation Inhibition Promotes Degradation of Tau in iNeurons.
Not available
S-EPMC12874043 | biostudies-literature
UnknownTranscriptome Analysis of iPSC-Derived Neurons from Rubinstein-Taybi Patients Reveals Deficits in Neuronal Differentiation.
Not available
S-EPMC7399686 | biostudies-literature
GenomicsCROPSeq of Putative AD- and PSP-associated cis-Regulatory Regions in iPSC-derived Neurons and Microglia
CROPSeq of Putative AD- and PSP-associated cis-Regulatory Regions in iPSC-derived Neurons and Microglia
PRJNA853730 | ENA
GenomicsThe deletion of the Williams-Beuren Syndrome critical region dysregulate the expression of miR379-410 miRNA members in human isogenic iNeurons
The deletion of the Williams-Beuren Syndrome critical region dysregulate the expression of miR379-410 miRNA members in human isogenic iNeurons
PRJNA1040287 | ENA
GenomicsTranscriptome analysis of iPSC-derived neurons from Rubinstein-Taybi patients reveals deficits in neuronal differentiation.
Transcriptome analysis of iPSC-derived neurons from Rubinstein-Taybi patients reveals deficits in neuronal differentiation.
PRJNA558248 | ENA
TranscriptomicsTranscriptome analysis of iPSC-derived neurons from Rubinstein-Taybi patients reveals deficits in neuronal differentiation.
Rubinstein-Taybi syndrome (RSTS) is a rare multisystem developmental disorder with moderate to severe intellectual disability caused by heterozygous mutations of either CREBBP or EP300 genes encoding CBP/p300 chromatin modifiers. We explored the gene programs and processes underlying the morphologic...
ORGANISM(S): Homo sapiens 
2020-06-24 | GSE135287 | GEO
ProteomicsRemodeling of the protein ubiquitylation landscape in the aging vertebrate brain
AQUA-PRM absolute quantification of ubiquitin-chains in human iPSC-derived neurons (iNeurons) upon bortezomib and/or bafilomycin treatments.
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2024-10-28 | MSV000096233 | MassIVE
GenomicsThe deletion of the Williams-Beuren Syndrome critical region dysregulate the expression of miR379-410 miRNA members in human isogenic iNeurons
While psychiatric disorders (e.g., schizophrenia) and autism spectrum disorders (ASD) are typically associated with a deficit in social behavior, the opposite trait of hypersociability is exhibited by individuals with specific neurodevelopmental disorders, e.g., Angelman Syndrome (AS) and Williams-B...
ORGANISM(S): Homo sapiens 
2023-11-15 | GSE247766 | GEO
GenomicsProfiling of gene expression using RNA-Seq in fibroblasts, iPSCs, iPSC-derived neurons and cells overexpressing Onecut transcription factors
Profiling of gene expression using RNA-Seq in fibroblasts, iPSCs, iPSC-derived neurons and cells overexpressing Onecut transcription factors
PRJNA491516 | ENA
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