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ProteomicsS-acylation of TDP43 regulates its condensation in amyotrophic lateral sclerosis
TDP43 inclusion bodies are widely present in the majority of patients with familial and sporadic amyotrophic lateral sclerosis (ALS). The mechanisms regulating TDP43 solubility remain incompletely understood. Here, we report that TDP43 undergoes S-acylation primarily at the Cys244 residue by the S-a...
ORGANISM(S): Homo sapiens (Human) 
2026-05-17 | PXD061643 | Pride
TranscriptomicsRibo-seq of iPSC-derived neurons with TDP-43 knockdown
TDP-43 is a key splicing regulator. Here, we perform ribosome profiling on iPSC-derived neurons to examine how translation is affected by TDP-43 knockdown.
ORGANISM(S): Homo sapiens 
2022-02-28 | E-MTAB-10235 | biostudies-arrayexpress
GenomicsNoncoding RNAs induce TDP43 pathology in the ALS-iPSC models
Noncoding RNAs induce TDP43 pathology in the ALS-iPSC models
PRJNA783184 | ENA
TranscriptomicsRapid and Inducible Mislocalization of Endogenous TDP43 in a Novel Human Model of Amyotrophic Lateral Sclerosis [Nanopore]
In this study, we describe the development of a new model of TDP43 proteinopathy using human induced pluripotent stem cell (iPSC)-derived neurons. Utilizing a genome engineering approach, we induced the mislocalization of endogenous TDP43 from the nucleus to the cytoplasm without mutating the TDP43 ...
ORGANISM(S): Homo sapiens 
2025-03-07 | GSE290441 | GEO
TranscriptomicsRapid and Inducible Mislocalization of Endogenous TDP43 in a Novel Human Model of Amyotrophic Lateral Sclerosis [miRNA-seq]
In this study, we describe the development of a new model of TDP43 proteinopathy using human induced pluripotent stem cell (iPSC)-derived neurons. Utilizing a genome engineering approach, we induced the mislocalization of endogenous TDP43 from the nucleus to the cytoplasm without mutating the TDP43 ...
ORGANISM(S): Homo sapiens 
2025-03-07 | GSE290437 | GEO
TranscriptomicsRapid and Inducible Mislocalization of Endogenous TDP43 in a Novel Human Model of Amyotrophic Lateral Sclerosis [RNA-seq]
In this study, we describe the development of a new model of TDP43 proteinopathy using human induced pluripotent stem cell (iPSC)-derived neurons. Utilizing a genome engineering approach, we induced the mislocalization of endogenous TDP43 from the nucleus to the cytoplasm without mutating the TDP43 ...
ORGANISM(S): Homo sapiens 
2025-03-07 | GSE290436 | GEO
GenomicsRapid and Inducible Mislocalization of Endogenous TDP43 in a Novel Human Model of Amyotrophic Lateral Sclerosis [miRNA-seq]
Rapid and Inducible Mislocalization of Endogenous TDP43 in a Novel Human Model of Amyotrophic Lateral Sclerosis [miRNA-seq]
PRJNA1228027 | ENA
GenomicsRapid and Inducible Mislocalization of Endogenous TDP43 in a Novel Human Model of Amyotrophic Lateral Sclerosis [RNA-seq]
Rapid and Inducible Mislocalization of Endogenous TDP43 in a Novel Human Model of Amyotrophic Lateral Sclerosis [RNA-seq]
PRJNA1228024 | ENA
GenomicsRapid and Inducible Mislocalization of Endogenous TDP43 in a Novel Human Model of Amyotrophic Lateral Sclerosis [Nanopore]
Rapid and Inducible Mislocalization of Endogenous TDP43 in a Novel Human Model of Amyotrophic Lateral Sclerosis [Nanopore]
PRJNA1228031 | ENA
UnknownMolecular Visualization of Neuronal TDP43 Pathology In Situ.
Not available
S-EPMC11370468 | biostudies-literature
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