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Idiopathic pulmonary fibrosis (IPF) is a complex disease involving various cell types. Macrophages are essential in maintenance of physiological homeostasis, wound repair and fibrosis in the lung. Macrophages play a crucial role in repair and remodeling by altering their phenotype and secretory patt...
ORGANISM(S): Rattus norvegicus 
Perturbation of healthy iPSC-CM with hsa-miR-134, hsa--433, and hsa-487b mimic and inhibitor
In this study, healthy iPSC-CM were transfected with hsa-miR-134, hsa--433, and hsa-487b mimic and inhibitor to study their effects on human cardiac proliferation after it was found that these miRNAs were enriched in maternal blood plasma within SVHD pregnancies. Mock and scramble were used as contr...
ORGANISM(S): Homo sapiens 
2024-10-02 | GSE266333 | GEO
Impact of regulatory variation across human iPSCs and differentiated cells [ATAC-seq iPSC-CM]
Trophoblast differentiation from human ESC has been achieved by exposing the cells to BMP4 with or without supplementation of ALK4/5/7 inhibitor (A83-01) and FGF2 signaling inhibitor (PD173074) (BAP). Here the two differentiation conditions, BMP4 and BAP were applied to two sets of human PSC lines, ...
ORGANISM(S): Homo sapiens 
Cardiac fibrosis occurs following insults to the myocardium and is characterized by the abnormal accumulation of non-compliant extracellular matrix (ECM), which compromises cardiomyocyte (CMs) contractile activity and eventually leads to heart failure. This phenomenon is driven by the differentiatio...
ORGANISM(S): Homo sapiens (Human) 
2025-05-06 | PXD049208 | Pride
RNA-seq was performed on cultured human induced pluripotent cell derived cardiomyocytes (iPSC-CMs). There are four groups, with three samples per group: H1,H2,H3. Negative control. Healthy, normoxic iPSC-CMs D1,D2,D3. Positive control. iPSCs cultured under hypoxic (0-1% O2) for 48h with 2% v/v PBS ...
ORGANISM(S): Homo sapiens 
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