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GenomicHypertension-Insulin Resistance Family Study (HTN-IR)

The HTN-IR Study, funded by NHLBI, was designed to explore genetic contributions to hypertension and glucose homeostasis traits among Hispanics using a family-based design. The baseline examination of the cohort included the euglycemic hyperinsulinemic clamp test from which the two key phenotypes...

phs001394 | dbGaP
TranscriptomicsCharacterization of Nicotiana attenuata plants with reduced expression of HD-Zip HD20 (ir-hd20 plants).
Identification of transcripts that change expression in corollas of Nicotiana attenuata plants with reduced expression of the transcription factor HD20. Gene expression in opening corollas of Nicotiana attenuata wild type and ir-hd20 plants was measured from isolated corollas collected at 12 pm. Thr...
ORGANISM(S): Nicotiana attenuata 
2013-12-24 | E-GEOD-33682 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human lymphoblastoid cell response to ultaviolet and ionising radiation
Peripheral blood lymphocytes from a total of 15 healthy individuals without history of cancer (NoCa) were immortalized with Epstein-Barr virus.

Cells were exposed to mock treatment (Mock), ultra-violet radiation (UV), or ionizing radiation (IR). For UV radiation treatment, cells were exposed...
ORGANISM(S): Homo sapiens 
2007-09-05 | E-GEOD-1977 | biostudies-arrayexpress
GenomicsSaccharomyces cerevisiae IR-2
Saccharomyces cerevisiae IR-2 genome sequencing
PRJDB1382 | ENA
TranscriptomicsCharacterization of Nicotiana attenuata plants with reduced expression of lectin receptor kinase 1 (ir-lecRK1 plants).
Identification of transcripts that change expression in Nicotiana attenuata plants with reduced expression of lectin receptor kinase 1 after elicitation with oral secretions of Manduca sexta larvae. Gene expression in leaves of Nicotiana attenuata wild type and ir-lecRK1 plants was measured at 1 hou...
ORGANISM(S): Nicotiana attenuata 
2011-11-23 | E-GEOD-29905 | biostudies-arrayexpress
ProteomicsEvaluation of iTRAQ and SWATH-MS for the quantification of proteins associated with insulin resistance in human duodenal biopsy samples
Insulin resistance (IR) is associated with increased production of triglyceride-rich lipoproteins of intestinal origin. In order to assess whether insulin resistance affects the proteins involved in lipid metabolism, we used two mass spectrometry based quantitative proteomics techniques to compare t...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
MSV000080194 | MassIVE
TranscriptomicsCharacterization of Nicotiana attenuata plants with reduced expression of HSPRO (ir-hspro plants).
Identification of transcripts that change expression in roots of Nicotiana attenuata plants with reduced expression of HSPRO and in association with Piriformospora indica. Gene expression in roots of Nicotiana attenuata wild type and ir-hspro seedlings was measured at 14 days after inoculation with ...
ORGANISM(S): Nicotiana attenuata 
2012-11-06 | E-GEOD-35086 | biostudies-arrayexpress
TranscriptomicsA novel insulin receptor-binding protein enhances glucose uptake and glucose clearance in vitro and in vivo through triggering insulin receptor signaling pathway
In this study, a novel IR-binding protein (IRBP) from Momordica charantia, named as mcIRBP, was identified by analyzing the physical and functional interactions between mcIRBP and IR. The hypoglycemic effect and mechanism of mcIRBP were further evaluated in normal and streptozotocin-induced diabetic...
ORGANISM(S): Mus musculus 
2016-06-25 | E-GEOD-48274 | biostudies-arrayexpress
TranscriptomicsSalivary Transcriptomic Biomarkers for Insulin Resistance
We have performed gene expression microarray analysis to profile transcriptomic signatures between insulin resistance high risk subjects and insulin resistance low risk subjects Participants enrolled in this study were recruited in the overnight fasted state, then the collection and processing of gl...
ORGANISM(S): Homo sapiens 
2015-04-10 | E-GEOD-67738 | biostudies-arrayexpress
GenomicsHelianthus annuus cultivar:IR
Helianthus annuus IR Genome sequencing and assembly
PRJNA841479 | ENA
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