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UnknownThe association between the tumor immune microenvironments and clinical outcome in low-grade, early-stage endometrial cancer patients.
Not available
S-EPMC9828119 | biostudies-literature
UnknownA core outcome set for studies evaluating the effectiveness of prepregnancy care for women with pregestational diabetes.
Not available
S-EPMC5487596 | biostudies-literature
MetabolomicsPeripheral modulation of antidepressant targets MAO-B and GABAAR by harmol induces mitohormesis and delays aging in preclinical models
Reversible and sub-lethal stresses to the mitochondria elicit a program of compensatory responses that ultimately improve mitochondrial function, a conserved anti-aging mechanism termed mitohormesis. Here, we show that harmol, a member of the beta-carbolines family with anti-depressant properties, i...
2023-05-26 | MTBLS7533 | MetaboLights
ProteomicsInvestigating Synthetic Lethality and PARP Inhibitor Resistance in Pancreatic Cancer Through Enantiomer Differential Activity
The RAD51-BRCA2 interaction is central to DNA repair through homologous recombination. Emerging evidence indicates RAD51 overexpression and its correlation with chemoresistance in various cancers, suggesting RAD51-BRCA2 inhibition as a compelling avenue for intervention. We previously showed that co...
ORGANISM(S): Homo sapiens (Human) 
2025-05-07 | PXD054120 | Pride
Anticancer drugs  homologous recombination  parp inhibitors  protein-protein small molecule inhibitors  parpi resistance  within-pathway synthetic lethality (wpsl) 
MetabolomicsAssessing the Feasibility of In Vitro Assays in Combination with Biological Matrices to Screen for Endogenous CYP450 Phenotype Biomarkers Using an Untargeted Metabolomics Approach—A Proof of Concept Study

Cytochrome P450 (CYP) enzymes are crucial for drug metabolism, yet inter-individual variability in their activity remains a significant clinical challenge. Current phenotyping methods are often impractical or even impossible, particularly in forensic toxicology and vulnerable populations. This pr...

2025-12-12 | MTBLS13325 | MetaboLights
UnknownDiscrimination, Reliability, Sensitivity, and Specificity of Robotic Surgical Proficiency Assessment With Global Evaluative Assessment of Robotic Skills and Binary Scoring Metrics: Results From a Randomized Controlled Trial.
Not available
S-EPMC10513364 | biostudies-literature
TranscriptomicsTranscriptional profiling of early differentiation of primary human mesenchymal stem cells into chondrocytes
Transcriptional profiling of undifferentiated MSCs, MSCs in 3D culture, early differentiation time-points 15m, 30m, 1h, 2h, 4h, 8h, 16h after induction with TGF-β3 and hyaluronic acid, and fully differentiated chondrocytes (21 days after induction) using RNA-seq in triplicates of clones.
ORGANISM(S): Homo sapiens 
2021-05-24 | E-MTAB-10476 | biostudies-arrayexpress
MetabolomicsMetabolomic profiling of Fraxinus excelsior genotypes tolerant or susceptible to ash dieback disease reveals changes in iridoid glycosides
European common ash, Fraxinus excelsior L., is currently threatened by Ash dieback (ADB) caused by the fungus, Hymenoscyphus fraxineus. To detect and identify metabolites that may be products of pathways important in contributing to resistance against H. fraxineus we performed untargeted metabolomic...
2016-11-09 | MTBLS372 | MetaboLights
UnknownSLC22A3 polymorphisms do not modify pancreatic cancer risk, but may influence overall patient survival.
Not available
S-EPMC5341046 | biostudies-literature
UnknownManagement of Asymptomatic Sporadic Nonfunctioning Pancreatic Neuroendocrine Neoplasms (ASPEN) ≤2 cm: Study Protocol for a Prospective Observational Study.
Not available
S-EPMC7785972 | biostudies-literature
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