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TranscriptomicsQuantitative proteomic analysis reveals maturation as a mechanism underlying glucocorticoid resistance in B lineage ALL and JNK inhibitors as a re-sensitising therapy
Glucocorticoids (GC) are pivotal in the treatment of childhood acute lymphoblastic leukaemia (ALL) but resistance is a continuing clinical problem with the underlying mechanisms still unclear. An isobaric tag proteomic approach was used to compare protein profiles of the B lineage ALL GC-sensitive c...
ORGANISM(S): Homo sapiens 
2015-09-02 | E-GEOD-63335 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of normal v early MDS v non-MDS anemia bone marrow CD34 cells to identify biomarkers of disease
Early, low risk IPSS (International Prognostic Scoring System) myelodysplasia (MDS) is a heterogeneous disorder where the molecular and cellular haematopoietic defects are poorly understood. To gain insight into this condition, we analyzed gene expression profiles of marrow CD34+ progenitor cells fr...
ORGANISM(S): Homo sapiens 
2007-09-20 | E-GEOD-2779 | biostudies-arrayexpress
UnknownA drug and ATP binding site in type 1 ryanodine receptor
Not available
EMPIAR-10997 | biostudies-other
UnknownAn immunostimulatory glycolipid that blocks SARS-CoV-2, RSV, and influenza infections in vivo.
Not available
S-EPMC10319732 | biostudies-literature
UnknownRandomized Trial of Hypofractionated, Dose-Escalated, Intensity-Modulated Radiation Therapy (IMRT) Versus Conventionally Fractionated IMRT for Localized Prostate Cancer.
Not available
S-EPMC6804854 | biostudies-literature
ProteomicsExtracellular Vesicles in COVID-19 convalescence can regulate T cell metabolism and function
Long-term T cell dysregulation has been reported following COVID-19 disease. Prolonged T cell activation is associated with initial disease severity and may be implicated mechanistically in the onset of long-covid symptoms. Here we assess the role of extracellular vesicles (EV) in regulating T cell ...
ORGANISM(S): Homo sapiens (Human) 
2023-06-28 | PXD043058 | Pride
Covid-19 Exosomes Extracellular vesicles 
UnknownLoss of Trefoil Factor 2 From Pancreatic Duct Glands Promotes Formation of Intraductal Papillary Mucinous Neoplasms in Mice.
Not available
S-EPMC5396548 | biostudies-literature
GenomicsClonal Evolution of Pre-Leukemic Hematopoietic Stem Cells Precedes Human Acute Myeloid Leukemia

Acute myeloid leukemia is an aggressive clonal malignancy of the bone marrow that is the direct result of sequential acquisition of mutations in a single lineage of cells. In this study, we investigate a model in which this mutational acquisition occurs serially in long-lived self-renewing hemato...

phs000549.v1.p1 | EGA
TranscriptomicsDNA methylation data from mouse hematopoietic progenitors
Genome-wide DNA methylation was studied to determine the methylome map of lymphoid and myeoloid commitment from hematopoietic progenitors We used custom Nimblegen microarrays to determine the genome-wide DNA methylation in FACs purified mouse hematopoietic progeniors We isolated genomic DNA from mou...
ORGANISM(S): Mus musculus 
2010-08-14 | E-GEOD-23110 | biostudies-arrayexpress
UnknownEvaluating the effectiveness and reliability of the Vibrant Soundbridge and Bonebridge auditory implants in clinical practice: Study design and methods for a multi-centre longitudinal observational study.
Not available
S-EPMC6046512 | biostudies-literature
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