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UnknownGenetic and pharmacological inhibition of XBP1 protects against APAP hepatotoxicity through the activation of autophagy.
Not available
S-EPMC8831621 | biostudies-literature
UnknownTandem mass tag-based quantitative proteomic profiling identifies candidate serum biomarkers of drug-induced liver injury in humans.
Not available
S-EPMC9984368 | biostudies-literature
ProteomicsNeddylation inhibition halts acetaminophen induced liver injury boosting anabolic cardiolipin pathway
Drug Induced-liver injury (DILI) is a significant cause of acute liver failure (ALF) and liver transplantation in the Western world. APAP overdose is a main contributor of DILI, leading to hepatocyte cell death through necrosis. Herein, we identified that neddylation, an essential post-translational...
ORGANISM(S): Mus Musculus 
PXD053221 |
ProteomicsDrug Induced Liver Injury Biomarker Discovery Data
Discovery proteomics was conducted on serum samples using tandem mass tagging for relative quantitation to discover potential new biomarkers of DILI.
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2022-07-01 | MSV000089782 | MassIVE
ProteomicsTandem Mass Tag-Based Quantitative Proteomic Profiling Identifies Novel Serum Biomarkers of Drug-Induced Liver Injury in Humans
Diagnosis of drug-induced liver injury (DILI) and its distinction from other liver diseases are significant challenges in drug development and clinical practice. In this study we identify, confirm, and replicate the biomarker performance characteristics of candidate proteins in a cohort of patients ...
ORGANISM(S): Homo Sapiens 
2024-01-04 | PXD034882 | panorama
UnknownLoss of humoral response 3 months after SARS-CoV-2 vaccination in the CKD spectrum: the multicentric SENCOVAC study.
Not available
S-EPMC9383183 | biostudies-literature
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