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TranscriptomicsTranscription profiling of human HepG2 cells to investigate global gene expression changes including drug metabolism and disposition induced by three-dimensional culture
We found constitutive upregulation and higher degree induction of drug metabolism and disposition-related genes in a three-dimensional HepG2 culture. The upregulated genes are those believed to be regulated by different regulatory factors. The global gene expression analysis by Affymetrix GeneChip i...
ORGANISM(S): Homo sapiens 
2009-03-08 | E-GEOD-12939 | biostudies-arrayexpress
TranscriptomicsHepatocytes-HepaRG reprogramming.
To identify the molecular mechanisms and environmental inducers contributing to reprogramming of hepatocytes into progenitors in HCC context, we used the HepaRG cell line as model. We performed transcriptomic analysis at various time-points during this process; 0h, 1h, 4h, 8h, 12h, 16h, 24h and 48h.
ORGANISM(S): Homo sapiens 
2013-12-05 | E-GEOD-52989 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of rat embryo ductus arteriosis after maternal vitamin A administration
The effects of retinoic acid/vitamin A signal on the transcriptional profile of the ductus arteriosus during development were examined. Experiment Overall Design: Total RNA samples were isolated from pooled tissues obtained from Wister rat embryos on embryonic day 19 and 21, and from neonates on th...
ORGANISM(S): Rattus norvegicus 
2008-06-12 | E-GEOD-3420 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of rat aorta and ductus arteriosus
The transcriptional profiles of the aorta and the ductus arteriosus during development were compared. Experiment Overall Design: Total RNA samples were isolated from pooled tissues obtained from Wister rat embryos on embryonic day 19 and 21, and from neonates on the day of birth (n>=120). The RNA w...
ORGANISM(S): Rattus norvegicus 
2008-06-12 | E-GEOD-3422 | biostudies-arrayexpress
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