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MetabolomicsColorectal cancer isobaric labeling for metabolite quantification
Not available
ORGANISM(S): Homo sapiens 
ST002420 | MetabolomicsWorkbench
MetabolomicsLipid Data Analyzer: Discrimination of isobaric pairs of lipid standards from different lipid subclasses (Control experiment 2)
Lipid Data Analyzer (LDA; http://genome.tugraz.at/lda2) provides automated and reliable annotation of lipid species and their molecular structures in high-throughput data from chromatography-coupled tandem mass spectrometry using embedded rule sets. Using various low- and high-resolution mass spectr...
2017-10-27 | MTBLS391 | MetaboLights
ProteomicsImplementation of Non‑Isobaric TMT Analogues for Accurate Precursor‑Level Quantification by plexDIA
Multiplexed Data-Independent Acquisition (plexDIA) aims to bridge the gap between the quantitative depth of DIA and the sample throughput of isobaric tag-based workflows. Here, we implement non‑isobaric sample multiplexing using commercially available, isotopically differentiated tandem mass tag (TM...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2026-09-07 | PXD078770 | Pride
Plexdia Tko standard Non-isobaric multiplexing Quantitative proteomics 
MetabolomicsOptimizing Deconvolution of Chimeric Fragmentation Spectra to reveal molecular structures of complex biological mixtures

Direct infusion mass spectrometry (DI-MS) offers a rapid, high-throughput analysis and, compared to liquid chromatography MS (LC-MS), a different analytical window into the composition of complex biological samples. However, the lack of chromatographic separation in DI-MS results in highly comple...

MTBLS13066 | MetaboLights
ProteomicsA Collision-induced Dissociation Cleavable Isobaric Tag for Peptide Fragment Ion-based Quantification in Proteomics
Fragment ion-based proteome quantification methods quantify peptides based on unique peptide fragment ions avoiding the issue of ratio distortion that is commonly observed for reporter ion-based quantification approaches. Herein, we present a novel approach that relies on a collision-induced dissoci...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2020-08-17 | PXD018790 | Pride
Isotopic labelling Proteomics Cid cleavable tag Fragment ion-based quantification Isobaric labelling 
ProteomicsIsobaric matching between runs and novel PSM-level normalization in MaxQuant strongly improve reporter ion-based quantification - mouse tissue dataset
Isobaric labeling has the promise of combining high sample multiplexing with precise quantification. However, normalization issues and the missing value problem of complete n-plexes hamper quantification across more than one n-plex. Here we applied two novel algorithms implemented in MaxQuant that s...
ORGANISM(S): Mus musculus (Mouse) 
2020-06-22 | PXD019880 | Pride
Match between runs Normalization Tandem mass tag Isobaric labeling Multiplexed quantification 
UnknownDual Fragmentation Isobaric Tags for Metabolomics.
Not available
S-EPMC12711190 | biostudies-literature
UnknownIncreased N,N-Dimethyl Leucine Isobaric Tag Multiplexing by a Combined Precursor Isotopic Labeling and Isobaric Tagging Approach.
Not available
S-EPMC6314838 | biostudies-literature
ProteomicsIsobaric matching between runs and novel PSM-level normalization in MaxQuant strongly improve reporter ion-based quantification - Peli1 knock-out mice dataset
Isobaric labeling has the promise of combining high sample multiplexing with precise quantification. However, normalization issues and the missing value problem of complete n-plexes hamper quantification across more than one n-plex. Here we introduce two novel algorithms implemented in MaxQuant that...
ORGANISM(S): Mus musculus (Mouse) 
2020-06-22 | PXD019881 | Pride
Match between runs Normalization Tandem mass tag Isobaric labeling Multiplexed quantification 
ProteomicsDetecting single amino acids and small peptides by combining isobaric tags and peptidomics
Single amino acids and small endogenous peptides play important roles in maintaining a properly functioning organism. These molecules are however currently only routinely identified in targeted approaches. In a small proof-of-concept mass spectrometry experiment we found that by combining isobaric t...
ORGANISM(S): Homo sapiens (Human) 
2019-06-26 | PXD012872 | Pride
Cerebrospinal fluid Tmt Isobaric peptidomics Peptidomics Tandem mass tag 
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