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MetabolomicsIsocitrate dehydrogenase-1/Glioma Fluxomics Study
Not available
ORGANISM(S): Homo sapiens 
ST000302 | MetabolomicsWorkbench
MetabolomicsMitochondrial KMT9 methylates DLAT to control pyruvate dehydrogenase activity and prostate cancer growth

Prostate cancer (PCa) growth depends on de novo lipogenesis controlled by the mitochondrial pyruvate dehydrogenase complex (PDC). In this study, we identified lysine methyltransferase (KMT)9 as a novel regulator of PDC activity. KMT9 is localized in mitochondria of PCa cells, but not in mitochond...

2024-12-10 | MTBLS2452 | MetaboLights
MetabolomicsUse of Aspartate Dehydrogenase by cancer cells
Not available
ORGANISM(S): Homo sapiens 
ST000154 | MetabolomicsWorkbench
TranscriptomicsPatient glioma microarray for Impaired histone demethylation contributes to the cell differentiation arrest induced by cancer-associated isocitrate dehydrogenase mutation
To study the effects of IDH mutations, we collected and performed gene expression microarray analysis with tumor specimens from patients with grade II-III oligodendroglioma. Sequencing for mutations of IDH1 and IDH2 was done. Gene expression was compared between IDH wildtype vs. mutant samples
ORGANISM(S): Homo sapiens 
2012-02-01 | E-MEXP-3239 | biostudies-arrayexpress
GenomicsInduction of sarcomas by mutant IDH2
More than 50% of patients with chondrosarcomas exhibit gain-of-function mutations in either isocitrate dehydrogenase 1 (IDH1) or IDH2. In this study, we performed genome-wide CpG methylation sequencing of chondrosarcoma biopsies and found that IDH mutations were associated with DNA hypermethylation ...
ORGANISM(S): Homo sapiens 
2013-10-21 | E-GEOD-50539 | biostudies-arrayexpress
GenomicsWhole exome sequencing analyses of human, IDH2-mutated, acute myeloid leukemia samples from patients before or during treatment with Enasidenib.
Mutations in isocitrate dehydrogenase 2 (IDH2) occur in many cancers including Acute Myeloid Leukemia (AML). In preclinical models mutant IDH2 causes partial hemopoietic differentiation arrest. Recently, we showed that single agent Enasidenib, a first-in-class, selective mutant IDH2 inhibitor, produ...
ORGANISM(S): Homo sapiens 
2018-08-13 | E-MTAB-6299 | biostudies-arrayexpress
GenomicsIsocitrate Dehydrogenase 1 Primes Group-3 Medulloblastomas For Cuproptosis
Isocitrate Dehydrogenase 1 Primes Group-3 Medulloblastomas For Cuproptosis
PRJNA1169346 | ENA
GenomicsIsoform switching as a mechanism of acquired resistance to isocitrate dehydrogenase inhibition
Isoform switching as a mechanism of acquired resistance to isocitrate dehydrogenase inhibition
PRJEB29267 | ENA
Genomics
Decifiency of NADP isocitrate dehydrogenase
PRJNA872936 | ENA
GenomicsImmune landscape of Isocitrate Dehydrogenase (IDH) stratified human gliomas [RNA-Seq]
Immune landscape of Isocitrate Dehydrogenase (IDH) stratified human gliomas [RNA-Seq]
PRJNA922462 | ENA
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