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TranscriptomicsExpression data of human lung adenocarcinoma cell line H441 treated with TTF-1/NKX2-1 siRNA and TGF-beta
We determined and analyzed the effect of TTF-1/NKX2-1 on Smad3/Smad4 binding sites by ChIP-sequencing. We used expression microarrays to evaluate the effect of TTF-1/NKX2-1 siRNA on TGF-beta-induced gene expressions. H441 cells were transfected with siRNAs and treated with TGF-beta for RNA extractio...
ORGANISM(S): Homo sapiens 
2014-07-27 | E-GEOD-49675 | biostudies-arrayexpress
TranscriptomicsEffect of TTF-1/NKX2-1 expression on TGF-beta induced gene expression in A549 lung cancer cell line.
TTF-1/NKX2-1 was expressed by adenoviral vector and changes in gene expression were determined by RNA-sequencing. A549 cells were infected with Ad-TTF-1 or Ad-LacZ vectors and stimulated with TGF-beta for 24 hours or left untreated. Expression of polyA RNA was determined.
ORGANISM(S): Homo sapiens 
2014-07-27 | E-GEOD-56356 | biostudies-arrayexpress
GenomicsSmad3, Smad4 and TTF-1/NKX2-1 binding sites in H441/A549 lung cancer cell lines
We evaluated the role of TTF-1/NKX2-1 on Smad3 and Smad4 binding in lung cancer cell lines. Smad3 binding sites in A549 cells and Smad3, Smad4, and TTF-1/NKX2-1 binding sites in H441 cells were determined by ChIP-seq.
ORGANISM(S): Homo sapiens 
2014-07-27 | E-GEOD-51509 | biostudies-arrayexpress
TranscriptomicsReduced expression of RBM47 enhances Nrf2 activity to promote tumor growth in A549 lung adenocarcinoma cells
We identified RNA binding motif protein 47 (RBM47) as a target gene of transforming growth factor (TGF)-beta in mammary gland epithelial cells (NMuMG cells) that have undergone the epithelial-to-mesenchymal transition (EMT). TGF-beta repressed RBM47 expression in NMuMG cells and lung cancer cell lin...
ORGANISM(S): Homo sapiens 
2016-03-01 | E-GEOD-61910 | biostudies-arrayexpress
UnknownDevelopment and validation of a prediction model for rehospitalization among people with schizophrenia discharged from acute inpatient care.
Not available
S-EPMC10483840 | biostudies-literature
UnknownSafety of liposomal daunorubicin-cytarabine (CPX-351) in secondary AML: Japanese phase 1/2 study and global phase 3 study.
Not available
S-EPMC12638407 | biostudies-literature
UnknownAn Id-like molecule, HHM, is a synexpression group-restricted regulator of TGF-beta signalling.
Not available
S-EPMC2570476 | biostudies-literature
UnknownA Smad3 and TTF-1/NKX2-1 complex regulates Smad4-independent gene expression.
Not available
S-EPMC4123303 | biostudies-literature
UnknownOligodendrocyte transcription factor 1 (Olig1) is a Smad cofactor involved in cell motility induced by transforming growth factor-β.
Not available
S-EPMC3696667 | biostudies-literature
UnknownRNA-binding motif protein 47 inhibits Nrf2 activity to suppress tumor growth in lung adenocarcinoma.
Not available
S-EPMC5036161 | biostudies-literature
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