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MetabolomicsShotgun lipidomics of HeLa whole-cell lysates and lysosomes following LLOMe treatment

Perturbations in lysosome integrity are tightly linked to neurological disorders and ageing, but the underlying pathogenic mechanisms are incompletely understood. Using an unbiased proteomic approach, we here identified the bridge-like lipid transport protein VPS13C/PARK23 as a key component of a...

2026-07-03 | MTBLS14737 | MetaboLights
UnknownImipramine Treatment Alters Sphingomyelin, Cholesterol, and Glycerophospholipid Metabolism in Isolated Macrophage Lysosomes.
Not available
S-EPMC10742328 | biostudies-literature
ProteomicsMFSD1 KO Liver - Lysosomes are a major site of intracellular acidic hydrolase-mediated proteolysis and cellular degradation
Lysosomes are a major site of intracellular acidic hydrolase-mediated proteolysis and cellular degradation. The export of low-molecular catabolic end products from the lysosomal lumen to the cytosol is facilitated by polytopic transmembrane proteins which mediate secondary active or passive transpor...
ORGANISM(S): Mus musculus (Mouse) 
2019-10-28 | PXD014241 | Pride
Lysosome Liver Mfsd1 
TranscriptomicsPeripheral positioning of lysosomes supports melanoma aggressiveness
Emerging evidences suggest that both function and position of organelles are pivotal for tumor cell dissemination. Among them, lysosomes stand out as they integrate metabolic sensing with gene regulation and secretion of proteases. Yet, how lysosomes function is linked to their position and thereby ...
ORGANISM(S): Homo sapiens 
2023-07-31 | E-MTAB-13165 | biostudies-arrayexpress
ProteomicsLabel free proteomics of isolated lysosomes from a wild type and LIMP2 knock out mouse
Quantitative label free proteomics on an n=1 experiment of isolated tritosomes (lysosomes) from mus musculus, WT and a knock out of the LIMP2 protein.
ORGANISM(S): Mus musculus (Mouse) 
2018-11-27 | PXD001633 | Pride
Proteomics Tritosome Mouse Lysosome Scrb2 
ProteomicsComprehensive proteomic analysis of mouse embryonic fibroblast lysosomes by mass spectrometry
The lysosome is the main degradative organelle in eukaryotic cells. It is involved in diverse cellular functions from intracellular digestion to metabolic signaling. Despite various efforts to enrich for lysosomes and analyze their proteome with mass spectrometry based proteomics approaches, no syst...
ORGANISM(S): Mus musculus (Mouse) 
2020-02-17 | PXD014576 | Pride
Lc-msms Dia Lysosome 
ProteomicsProteome Composition of Lysosomes and Autophagosomes after Proteasome Inhibition
Lysosomes are a major site of intracellular acidic hydrolase-mediated proteolysis and cellular degradation in a membrane-enclosed organelle. Alternatively, soluble, ubiquitin-bound proteins are degraded via the proteasome, a megadalton protein complex within the cytoplasm. The interplay between both...
ORGANISM(S): Homo sapiens (Human) 
2020-04-20 | PXD015243 | Pride
Proteaphagy Lysosome Proteasome 
UnknownDirect electrochemical observation of glucosidase activity in isolated single lysosomes from a living cell.
Not available
S-EPMC5910846 | biostudies-literature
UnknownTagless LysoIP for immunoaffinity enrichment of native lysosomes from clinical samples.
Not available
S-EPMC11827837 | biostudies-literature
ProteomicsIdentification of the late endosome LE/MVB proteome related to the endosomal microautophagy eMI activity in the rat liver.
To identify the late endosome LE/MVB proteome related to the endosomal microautophagy eMI activity we purified subcellular organelles including cytosol, late endosomes (LE/MVBs) and lysosomes (CMA+) from the rat liver and performed co-Ip experiment with antibodies directed against the major cellular...
ORGANISM(S): Rattus norvegicus (Rat) 
2024-01-26 | PXD046797 | Pride
Cma vs microautophagy  hsc-70-co-ip-ms/ms in late endosomes Rat liver Lysosomes and cytosol 
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