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TranscriptomicsThe Small Molecule ISRIB Reverses the Effects of eIF2α Phosphorylation on Translation and Stress Granule Assembly
We recently identified ISRIB as a potent inhibitor of the integrated stress response (ISR). ISRIB renders cells resistant to the effects of eIF2α phosphorylation and enhances long-term memory in rodents (10.7554/eLife.00498). Here we show by genome-wide in vivo ribosome profiling that translation o...
ORGANISM(S): Homo sapiens 
2015-02-27 | E-GEOD-65778 | biostudies-arrayexpress
GenomicsMolecular effects of ISRIB during asparagine deprivation
Molecular effects of ISRIB during asparagine deprivation
PRJNA521363 | ENA
TranscriptomicsDeficiency of ERO1 and activation of protein translation synergistically impair breast tumor resilience
Endoplasmic reticulum (ER) stress triggers an adaptive response which fosters tumor cell survival and resilience to stress conditions. Activation of the endoplasmic reticulum stress response, through its PERK branch, promotes the phosphorylation of the α-subunit of translation initiation factor eIF2...
ORGANISM(S): Homo sapiens 
2022-07-20 | E-MTAB-11313 | biostudies-arrayexpress
UnknownBinding of ISRIB reveals a regulatory site in the nucleotide exchange factor eIF2B.
Not available
S-EPMC5889100 | biostudies-literature
TranscriptomicsThe Small Molecule ISRIB Reverses the Effects of eIF2α Phosphorylation on Translation and Stress Granule Assembly
We recently identified ISRIB as a potent inhibitor of the integrated stress response (ISR). ISRIB renders cells resistant to the effects of eIF2α phosphorylation and enhances long-term memory in rodents (10.7554/eLife.00498). Here we show by genome-wide in vivo ribosome profiling that translation of...
ORGANISM(S): Homo sapiens 
2015-02-27 | GSE65778 | GEO
UnknownModulating the unfolded protein response with ISRIB mitigates cisplatin ototoxicity.
Not available
S-EPMC11437005 | biostudies-literature
UnknownThe small molecule ISRIB reverses the effects of eIF2α phosphorylation on translation and stress granule assembly.
Not available
S-EPMC4341466 | biostudies-literature
UnknownISRIB Blunts the Integrated Stress Response by Allosterically Antagonising the Inhibitory Effect of Phosphorylated eIF2 on eIF2B.
Not available
S-EPMC7837216 | biostudies-literature
UnknownThe small molecule ISRIB rescues the stability and activity of Vanishing White Matter Disease eIF2B mutant complexes.
Not available
S-EPMC5829914 | biostudies-literature
TranscriptomicsISRIB can temporarily maintain the cell fate of human trophoblast stem cell without activating WNT and inhibiting TGFβ
To investigate the role of ISRIB in human trophoblast stem cell(hTSC) maintenance without activation of WNT & TGFβ. We performed gene expression profiling analysis using data obtained from RNA-seq of hTSCs cultured in the medium contained 0.5 µM ISRIB and 10 µM Y27652, after removing CHIR99021, A83-...
ORGANISM(S): Homo sapiens 
2023-12-31 | GSE221409 | GEO
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