Sort   by:  
 Page size 
TranscriptomicsLost miRNA surveillance of NOTCH, IGFR pathway-road to sarcomagenesis
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Homo sapiens 
2013-08-28 | E-GEOD-48420 | biostudies-arrayexpress
TranscriptomicsLost miRNA surveillance of NOTCH, IGFR pathway-road to sarcomagenesis [Exiqon]
The goal of this study was comparative analysis of differentially expressed miRNA and their targets in human chondrosarcoma JJ012 and chondrocytes C28 cell line (control) to elucidate the major signal transduction pathways deregulation in sarcomagenesis. Total RNA extraction was followed by the anal...
ORGANISM(S): Homo sapiens 
2013-08-28 | E-GEOD-48396 | biostudies-arrayexpress
TranscriptomicsLost miRNA surveillance of NOTCH, IGFR pathway-road to sarcomagenesis [Illumina]
The goal of this study was comparative analysis of differentially expressed miRNA and their targets in human chondrosarcoma JJ012 and chondrocytes C28 cell line(control) to elucidate the major signal transduction pathways deregulation in sarcomagenesis. Total RNA extraction was followed by the analy...
ORGANISM(S): Homo sapiens 
2013-08-28 | E-GEOD-48418 | biostudies-arrayexpress
TranscriptomicsRegulation of onco and tumor suppressor miRNA by mTORC1 inhibitor PRP-1 in human chondrosarcoma
The goal of this study was comparative analysis of differentially expressed miRNA and their targets in human chondrosarcoma JJ012 not treated (Control) and JJ012 chondrosarcoma cell line treated with antitumorigenic neuropeptide PRP-1. The goal was to elucidate the major signal transduction pathw...
ORGANISM(S): Homo sapiens 
2013-10-31 | E-GEOD-49545 | biostudies-arrayexpress
TranscriptomicsIntrinsic self-DNA triggers inflammatory disease dependent on STING
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Mus musculus 
2014-07-09 | E-GEOD-59219 | biostudies-arrayexpress
TranscriptomicsInflammation-Driven Carcinogenesis is Mediated through STING
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Mus musculus 
2014-05-31 | E-GEOD-57605 | biostudies-arrayexpress
TranscriptomicsCyclic-Di-Nucleotides Trigger ULK1 (ATG1) Phosphorylation of STING to Prevent Sustained Innate Immune Signaling
Activation of the STING (Stimulator of Interferon Genes) pathway by microbial or self-DNA, as well as cyclic di nucleotides (CDN), results in the induction of numerous genes that suppress pathogen replication and facilitate adaptive immunity. However, sustained gene transcription is rigidly prevente...
ORGANISM(S): Mus musculus 
2013-10-10 | E-GEOD-51199 | biostudies-arrayexpress
TranscriptomicsIntrinsic self-DNA triggers inflammatory disease dependent on STING (I)
Inflammatory diseases such as Aicardi-Goutieres Syndrome (AGS) and severe systemic lupus erythematosus (SLE) are generally lethal disorders that have been traced to defects in the exonuclease Trex1 (DNAseIII). Mice lacking Trex1 similarly die at an early age through comparable symptoms, including in...
ORGANISM(S): Mus musculus 
2014-07-09 | E-GEOD-59217 | biostudies-arrayexpress
TranscriptomicsIntrinsic self-DNA triggers inflammatory disease dependent on STING (II)
Inflammatory diseases such as Aicardi-Goutieres Syndrome (AGS) and severe systemic lupus erythematosus (SLE) are generally lethal disorders that have been traced to defects in the exonuclease Trex1 (DNAseIII). Mice lacking Trex1 similarly die at an early age through comparable symptoms, including in...
ORGANISM(S): Mus musculus 
2014-07-09 | E-GEOD-59218 | biostudies-arrayexpress
TranscriptomicsNotch1 - WISP1 Axis Determines Tumor-Regulating Role of Melanoma Stromal Fibroblasts
Cancer-associated fibroblasts (CAF) are crucial in regulating cancer progression, yet the molecular mechanisms that determine the tumor-regulating function of CAF are poorly understood. Here, we uncover the Notch1 pathway as a molecular determinant that controls the regulatory role of CAF in mela...
ORGANISM(S): Mus musculus 
2016-05-29 | E-GEOD-65316 | biostudies-arrayexpress
Sort   by:  
 Page size