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ProteomicsIdentification of proteins present in LACTB solutions overexpressed and purified from E.coli by LC-MS/MS.
Non-enzymatic D-isomerization of aspartic acid in proteins has been observed in lesions associated with age-related diseases, including cataracts and Alzheimer's disease. Since D-isomerization of Asp disrupts the physiological conformation of proteins, it has been postulated that D-isomerization of ...
ORGANISM(S): Escherichia Coli 
2025-04-19 | PXD062910 | JPOST Repository
TranscriptomicsAgilent HSC
Under conditions of the liver exposed to chronic insults such as viral infection, excess deposition of fat, regurgitation of bile acids etc., hepatic stellate cells (HSCs) change from quiescent to activated states and proliferate. During this process, HSCs secrete collagen and metalloproteinases. In...
ORGANISM(S): Rattus norvegicus 
2014-05-26 | E-MTAB-2081 | biostudies-arrayexpress
ProteomicsThe mouse aging proteomic atlas
This database provides TMT-labeled proteomic data of aorta (thoracic aorta), brain, heart, kidney, liver, lung, muscle (gastrocnemius muscle), and skin (abdominal skin) of 6, 15, 24, and 30 months old male C57BL/6 mice. In addition to the whole-tissue lysate, low-soluble protein-enriched fraction wa...
ORGANISM(S): Mus musculus (Mouse) 
2024-09-17 | PXD040722 | Pride
Proteome Aging Multi-omics 
TranscriptomicsInteractions of cytokines in peripheral blood cells from Systemic Lupus Erythematosus
SLE patients are always with various disease manifestation. Various cytokines are pointed interacting and playing pathological roles in SLE although the etiopathology is still obscure. In this study, we aimed to investigate the effects of cytokine interactions in the immune response of SLE patients....
ORGANISM(S): Homo sapiens 
2009-05-31 | E-GEOD-12374 | biostudies-arrayexpress
TranscriptomicsDevelopment of miRNA expression signatures of MEFs deficient in a ER stress mediator ATF6a for tunicamycin treatment
To further development of our miRNA expression approach to ER stress, we have employed miRNA microarray expression profiling as a discovery platform to identify ER stress-responsible ones. Mouse embryonic fibroblasts (MEFs) deficient in a ER stress mediator ATF6a were treated with tunicamycin for ...
ORGANISM(S): Mus musculus 
2015-01-18 | E-GEOD-35176 | biostudies-arrayexpress
TranscriptomicsDevelopment of miRNA expression signatures of MEFs deficient in a ER stress mediator XBP1 for tunicamycin treatment
To further development of our miRNA expression approach to ER stress, we have employed miRNA microarray expression profiling as a discovery platform to identify ER stress-responsible ones. Mouse embryonic fibroblasts (MEFs) deficient in a ER stress mediator XBP1 were treated with tunicamycin for 1...
ORGANISM(S): Mus musculus 
2015-01-18 | E-GEOD-35174 | biostudies-arrayexpress
TranscriptomicsDevelopment of miRNA expression signatures of MEFs deficient in a ER stress mediator ATF4 for tunicamycin treatment
To further development of our miRNA expression approach to ER stress, we have employed miRNA microarray expression profiling as a discovery platform to identify ER stress-responsible ones. Mouse embryonic fibroblasts (MEFs) deficient in a ER stress mediator ATF4 were treated with tunicamycin for 1...
ORGANISM(S): Mus musculus 
2015-01-18 | E-GEOD-35175 | biostudies-arrayexpress
TranscriptomicsDevelopment of mRNA and lincRNA expression signatures of MEFs deficient in ER stress mediators for tunicamycin treatment
To further development of our mRNA or lincRNA expression approach to ER stress, we have employed whole genome microarray expression profiling as a discovery platform to identify ER stress-responsible genes. Mouse embryonic fibroblasts (MEFs) deficient in each ER stress mediator (XBP1, ATF4, ATF6a ...
ORGANISM(S): Mus musculus 
2015-01-18 | E-GEOD-35173 | biostudies-arrayexpress
TranscriptomicsDevelopment of miRNA expression signatures of MEFs deficient in a ER stress mediator ATF6b for tunicamycin treatment
To further development of our miRNA expression approach to ER stress, we have employed miRNA microarray expression profiling as a discovery platform to identify ER stress-responsible ones. Mouse embryonic fibroblasts (MEFs) deficient in a ER stress mediator ATF6b were treated with tunicamycin for ...
ORGANISM(S): Mus musculus 
2015-01-18 | E-GEOD-35177 | biostudies-arrayexpress
TranscriptomicsGene expression profile of ATF6a and ATF6b knockout mice with dextran sulfate sodium (DSS)-induced colitis
To understand the role of ATF6a and ATF6b in non-canonical endoplasmic reticulum stress response pathway, we have employed whole genome microarray expression profiling to identify the genes regulated by ATF6s. WIild type or, ER stress mediators,ATF6a or ATF6b-knockout mice were treated with 3% DSS ...
ORGANISM(S): Mus musculus 
2015-02-08 | E-GEOD-35651 | biostudies-arrayexpress
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