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TranscriptomicsmTOR inhibitors synergistically induce regression, reversal of gene expression and autophagy in hepatocellular carcinoma
The mTOR-allosteric inhibitor, RAD001, in combination with a PI3K/mTOR ATP-site competitive inhibitor, BEZ235, causes gene reprogramming, autophagy and tumor regression, in a mouse model approximating human HCC with poor prognosis, leading to an investigator Phase 1B-2 clinical trial. Comparative st...
ORGANISM(S): Mus musculus 
2012-07-11 | E-GEOD-37129 | biostudies-arrayexpress
TranscriptomicsPretreatment with Gamma-Secretase Inhibitor Prevents Tumor-Like Overgrowth in Human iPSC-Derived Transplant for Spinal Cord Injury
Cell cycle- and more mature neuronal marker-related genes increased by > 2-fold change in both the GSI groups compared to the control group. To analyze gene expression profiles in hiPSC-NS/PCs treated with or without Gamma-secretase inhibitor.
ORGANISM(S): Homo sapiens 
2016-01-06 | E-GEOD-76556 | biostudies-arrayexpress
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