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TranscriptomicsMethylation profiling data from medulloblastoma tumor samples
Smoothened (SMO)-inhibitors recently entered clinical trials for sonic-hedgehog driven medulloblastoma (SHH-MB). Clinical response appears highly variable. To understand the mechanism(s) of primary resistance and to identify pathways co-operating with aberrant SHH-signaling, we sequenced a large coh...
ORGANISM(S): Homo sapiens 
2014-09-02 | E-GEOD-49377 | biostudies-arrayexpress
TranscriptomicsMethylation data from medulloblastoma tumor samples
Smoothened (SMO)-inhibitors recently entered clinical trials for sonic-hedgehog driven medulloblastoma (SHH-MB). Clinical response appears highly variable. To understand the mechanism(s) of primary resistance and to identify pathways co-operating with aberrant SHH-signaling, we sequenced a large coh...
ORGANISM(S): Homo sapiens 
2014-09-02 | E-GEOD-49576 | biostudies-arrayexpress
UnknownPhenotypic and transcriptomic impact of expressing mammalian TET2 in the Drosophila melanogaster model.
Not available
S-EPMC10072067 | biostudies-literature
GenomicsH3.3G34W promotes growth and impedes differentiation of osteoblast-like mesenchymal progenitors in Giant Cell Tumour of Bone [RNA-Seq]
H3.3G34W promotes growth and impedes differentiation of osteoblast-like mesenchymal progenitors in Giant Cell Tumour of Bone [RNA-Seq]
PRJNA627673 | ENA
TranscriptomicsFrequent driver mutations in histone H3.3 and chromatin remodeling genes in paediatric glioblastoma
Whole exome sequencing identified frequent driver mutations in a series of paediatric glioblastomas We used microarray-based profiling to investigate differences in gene expression according to mutational status of driver genes RNA from 27 primary tumor samples was subject to QC by Agilent BioAnalys...
ORGANISM(S): Homo sapiens 
2012-03-01 | E-GEOD-34824 | biostudies-arrayexpress
UnknownOncohistones: a roadmap to stalled development.
Not available
S-EPMC9990449 | biostudies-literature
UnknownPolycomb repressive complex 2 in the driver's seat of childhood and young adult brain tumours.
Not available
S-EPMC8448921 | biostudies-literature
GenomicsHomo sapiens
H3.3K27M cooperates with p53 loss and Pdgfra gain in mouse embryonic neural progenitor cells to induce invasive high-grade gliomas [Human RNA-Seq]
PRJNA376547 | ENA
GenomicsSHH medulloblastoma samples
Sequencing data of human SHH medulloblastoma samples
EGAS00001000607 | EGA
UnknownCharacterizing temporal genomic heterogeneity in pediatric high-grade gliomas.
Not available
S-EPMC5663045 | biostudies-literature
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