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ProteomicsLow neoantigen expression and poor T cell priming underlie early immune escape in cancer
Low neoantigen expression and poor T cell priming underlie early immune escape in cancer
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2021-06-17 | MSV000087648 | MassIVE
GenomicsConcurrently expressed tumor neoantigens drive phenotypically distinct CD8 T cell responses
Concurrently expressed tumor neoantigens drive phenotypically distinct CD8 T cell responses
PRJNA689431 | ENA
GenomicsNkx2-1 Represses a Latent Gastric Differentiation Program in Lung Adenocarcinoma
Tissue-specific differentiation programs become dysregulated during cancer evolution. The transcription factor Nkx2-1 is a master regulator of pulmonary differentiation that is downregulated in poorly differentiated lung adenocarcinoma. Here we use conditional murine genetics to study the fate of l...
ORGANISM(S): Mus musculus 
2013-04-09 | E-GEOD-43252 | biostudies-arrayexpress
TranscriptomicsStage-specific sensitivity to p53 restoration in lung cancer: cell line data
Tumorigenesis is a multistep process that results from the sequential accumulation of mutations in key oncogene and tumor-suppressor pathways. The quest to personalize cancer medicine based on targeting these underlying genetic abnormalities presupposes that sustained inactivation of tumor suppresso...
ORGANISM(S): Mus musculus 
2010-11-24 | E-GEOD-23873 | biostudies-arrayexpress
TranscriptomicsProliferation and Tumorigenesis of a Murine Sarcoma Cell Line in the Absence of Dicer
MicroRNAs are a class of short ~22 nucleotide RNAs predicted to regulate nearly half of all protein-coding genes, including many involved in basal cellular processes and organismal development. Although both increases and decreases in the levels of specific miRNAs have been shown to promote tumor d...
ORGANISM(S): Mus musculus 
2012-08-20 | E-GEOD-34825 | biostudies-arrayexpress
TranscriptomicsStage-specific sensitivity to p53 restoration in lung cancer: tumor data
Tumorigenesis is a multistep process that results from the sequential accumulation of mutations in key oncogene and tumor-suppressor pathways. The quest to personalize cancer medicine based on targeting these underlying genetic abnormalities presupposes that sustained inactivation of tumor suppresso...
ORGANISM(S): Mus musculus 
2010-11-24 | E-GEOD-23874 | biostudies-arrayexpress
TranscriptomicsSuppression of Lung Adenocarcinoma Progression by Nkx2-1
Despite the high prevalence and poor outcome of patients with metastatic lung cancer, the mechanisms of tumour progression and metastasis remain largely uncharacterized. We modelled human lung adenocarcinoma, which frequently harbours activating point mutations in KRAS1 and inactivation of the p53-p...
ORGANISM(S): Mus musculus 
2011-01-27 | E-GEOD-26874 | biostudies-arrayexpress
TranscriptomicsProgressive genomic instability in the FVB/KrasLA2 mouse model of lung cancer
Alterations in DNA copy number contribute to the development and progression of cancers and are common in epithelial tumors. We have used array Comparative Genomic Hybridization (aCGH) to visualize DNA copy number alterations across the genomes of lung tumors in the KrasLA2 model of lung cancer. C...
ORGANISM(S): Mus musculus 
2011-11-22 | E-GEOD-29230 | biostudies-arrayexpress
TranscriptomicsAtp4b-Cre;Cdh1(fl/fl);Kras(LSL-G12D/+);Trp53(fl/fl);Rosa26(LSL-YFP/LSL-YFP) mouse stomach vs. Atp4b-Cre;Cdh1(fl/+);Kras(LSL-G12D/+);Trp53(fl/fl);Rosa26(LSL-YFP/LSL-YFP) mouse stomach microarray
We wished to investigate the role of E-cadherin loss in our mouse parietal cell/pre-parietal cell E-cadherin knock-out, p53 knock-out, oncogenic Kras induced model of gastric cancer. As such, we isolated RNA from stomach tissue from our E-cadherin knock-out model (Atp4b-Cre;Cdh1(fl/fl);Kras(LSL-G12D...
ORGANISM(S): Mus musculus 
2018-05-01 | E-MTAB-5833 | biostudies-arrayexpress
TranscriptomicsUndifferentiated Pleomorphic Sarcoma Model
Analysis of undifferentiated pleomorphic sarcoma/malignant fibrous histiocytoma-like tumors from LSL-KrasG12D, p53Fl/Fl mouse model of soft tissue sarcoma. Murine soft tissue sarcomas (n = 17) were compared to normal muscle (n = 4). Tumors were isolated surgically from soft tissue sarcomas generate...
ORGANISM(S): Mus musculus 
2010-03-03 | E-GEOD-16779 | biostudies-arrayexpress
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