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TranscriptomicsNovel Observations from Next Generation RNA Sequencing of Highly Purified Human Adult and Fetal Islet Cell Subsets
Understanding distinct gene expression patterns of normal adult and developing fetal human pancreatic a and b cells is crucial for developing stem cell therapies, islet regeneration strategies, and therapies designed to increase b cell function in patients with diabetes (type 1 or 2). Toward that en...
ORGANISM(S): Homo sapiens 
2015-06-08 | E-GEOD-67543 | biostudies-arrayexpress
TranscriptomicsFASCIATED EAR4 encodes a bZIP transcription factor that controls shoot meristem size in maize
fasciated ear4 (fea4) is a semi-dwarfed mutant with fasciated ears and tassels, and greatly enlarged vegetative and inflorescence meristems. Chromatin Immunoprecipitation-sequencing (ChIP-seq) and expression profiling by RNA-seq suggest that fea4 is required to regulate the auxin response and leaf ...
ORGANISM(S): Zea mays 
2015-01-21 | E-GEOD-61954 | biostudies-arrayexpress
UnknownMutational Spectrum, Copy Number Changes, and Outcome: Results of a Sequencing Study of Patients With Newly Diagnosed Myeloma.
Not available
S-EPMC6485456 | biostudies-literature
MetabolomicsAntiviral metabolite 3'-Deoxy-3',4'-didehydro-cytidine is detectable in serum and identifies acute viral infections including COVID-19

BACKGROUND: There is a critical need for rapid viral infection diagnostics to enable prompt case identification in pandemic settings and support targeted antimicrobial prescribing.

METHODS: Using untargeted high-resolution liquid chromatography coupled with...

2022-02-10 | MTBLS718 | MetaboLights
ProteomicsMultiple reaction monitoring assays for large-scale quantitation of proteins from 20 mouse organs and tissues
We developed 6,927 quantitative multiple reaction monitoring mass spectrometry (MRM-MS) assays that measure 2,187 unique proteins in 20 mouse organs and tissues to enable system-level analysis of protein expression in mice. Targets for assay development were selected by untargeted MS analysis, and c...
ORGANISM(S): Mus Musculus 
2024-01-04 | PXD020930 | panorama
TranscriptomicsEMT is the dominant program in human colon cancer (Agilent)
mRNA profiles on 129 colorectal tumors 129 colorectal tumors profiled on Agilent array using pool of individual tumors as common reference
ORGANISM(S): Homo sapiens 
2011-04-25 | E-GEOD-28722 | biostudies-arrayexpress
UnknownLong-term outcomes after gene therapy for adenosine deaminase severe combined immune deficiency.
Not available
S-EPMC8525336 | biostudies-literature
UnknownStimulating Soluble Guanylyl Cyclase with the Clinical Agonist Riociguat Restrains the Development and Progression of Castration-Resistant Prostate Cancer.
Not available
S-EPMC11695179 | biostudies-literature
Genomicsena-DATASET-UAMS-17-03-2019-03:57:35:391-32 - samples
Series of 56 paired presentation, relapse and control samples from newly diagnosed, uniformly treated myeloma patients. Deep of treatment response and maintenance allocation (active observation or lenaldiomide) was determined for all. All samples underwent whole exome sequencing with additional bait...
EGAD00001004846 | EGA
MetabolomicsA mitochondrial NADPH-cholesterol axis regulates extracellular vesicle biogenesis to support hematopoietic stem cell fate

Mitochondrial fatty acid oxidation (FAO) is essential for hematopoietic stem cell (HSC) self-renewal; however, the mechanism by which mitochondrial metabolism controls HSC fate remains unknown. Here, we show that within the hematopoietic lineage, HSCs have the largest mitochondrial NADPH pools, w...

2025-07-07 | MTBLS6401 | MetaboLights
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