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TranscriptomicsTranscription profiling of mouse PyV-MT treated with conjugated linoleic acid reveals it suppresses FAS and promotes mammary tumorigenesis in mice
Overexpression of fatty acid synthase (FAS) has been reported in both malignant and premalignant breast lesions, and has been associated with poor outcome. FAS has gained interest as a metabolic target for the treatment of breast cancer based on evidence that blockade with the antifungal antibiotic,...
ORGANISM(S): Mus musculus 
2008-06-11 | E-GEOD-10193 | biostudies-arrayexpress
UnknownFunctional profiling of single CRISPR/Cas9-edited human long-term hematopoietic stem cells.
Not available
S-EPMC6802205 | biostudies-literature
TranscriptomicsThe Aryl Hydrocarbon Receptor Regulates Tissue-Specific Dioxin-Dependent and Dioxin-Independent Gene Batteries: Liver
The aryl hydrocarbon receptor (AHR) is a widely-expressed ligand-dependent transcription-factor that mediates cellular responses to dioxins and other planar aromatic hydrocarbons. Indeed, AHR-null mice are refractory to the physiological effects of dioxin-exposure. Although some mechanistic aspects ...
ORGANISM(S): Mus musculus 
2009-09-21 | E-GEOD-15858 | biostudies-arrayexpress
TranscriptomicsThe Aryl Hydrocarbon Receptor Regulates Tissue-Specific Dioxin-Dependent and Dioxin-Independent Gene Batteries: Kidney
The aryl hydrocarbon receptor (AHR) is a widely-expressed ligand-dependent transcription-factor that mediates cellular responses to dioxins and other planar aromatic hydrocarbons. Indeed, AHR-null mice are refractory to the physiological effects of dioxin-exposure. Although some mechanistic aspects ...
ORGANISM(S): Mus musculus 
2009-09-21 | E-GEOD-15857 | biostudies-arrayexpress
GenomicsMRC HGU IGMM Edinburgh DAC
Data Access Committee EGAC00001000393
EGAC00001000393 | EGA
UnknownMetformin reduces the competitive advantage of Dnmt3a<sup>R878H</sup> HSPCs.
Not available
S-EPMC12869297 | biostudies-literature
UnknownMetformin reduces the clonal fitness of <i>Dnmt3a</i> <sup>R878H</sup> hematopoietic stem and progenitor cells by reversing their aberrant metabolic and epigenetic state.
Not available
S-EPMC10889081 | biostudies-literature
Genomicsena-DATASET-MRCHGUIGMM-07-10-2015-09:16:27:050-356 - samples
BAM files for two WES TRAIP patients
EGAD00001001633 | EGA
GenomicsTRAIP promotes DNA damage response during genome replication and is mutated in primordial dwarfism
DNA lesions encountered by replicative polymerases threaten genome stability and cell cycle progression. Here we report the identification of mutations in TRAIP, encoding an E3 RING ubiquitin ligase, in patients with microcephalic primordial dwarfism/Seckel syndrome. We establish that TRAIP relocali...
EGAS00001001501 | EGA
UnknownGlioblastoma in adults: a Society for Neuro-Oncology (SNO) and European Society of Neuro-Oncology (EANO) consensus review on current management and future directions.
Not available
S-EPMC7594557 | biostudies-literature
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