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TranscriptomicsAtp4b-Cre;Cdh1(fl/fl);Kras(LSL-G12D/+);Trp53(fl/fl);Rosa26(LSL-YFP/LSL-YFP) mouse stomach vs. Atp4b-Cre;Cdh1(fl/+);Kras(LSL-G12D/+);Trp53(fl/fl);Rosa26(LSL-YFP/LSL-YFP) mouse stomach microarray
We wished to investigate the role of E-cadherin loss in our mouse parietal cell/pre-parietal cell E-cadherin knock-out, p53 knock-out, oncogenic Kras induced model of gastric cancer. As such, we isolated RNA from stomach tissue from our E-cadherin knock-out model (Atp4b-Cre;Cdh1(fl/fl);Kras(LSL-G12D...
ORGANISM(S): Mus musculus 
2018-05-01 | E-MTAB-5833 | biostudies-arrayexpress
TranscriptomicsMurine Schistosoma-Induced Pulmonary Hypertension: RNA-seq Data
Whole lung RNA-seq of 8 mice with experimental Schistosoma-induced pulmonary hypertension, compared to 8 control mice. All mice on a C57Bl6/J background. 3 schisto-PH and 3 control mice (#s 1-3 in each group) were also processed by Affy microarray and separately submitted. 3 of the mice in each grou...
ORGANISM(S): Mus musculus 
2013-07-23 | E-GEOD-49114 | biostudies-arrayexpress
TranscriptomicsGene expression in LCMV-specific Blimp-1 deficient effector CD8+ T cells compared to wildtype effector CD8+ T cells
Antigen-specific effector CD8+ T cells deficient in Blimp-1 (Prdm1) do not acquire maximal effector functions, evade terminal differentiation, and more rapidly acquire some hallmark properties of memory CD8+ T cells. In this study, we compared the gene expression profiles of wildtype and Prdm1-/- LC...
ORGANISM(S): Mus musculus 
2010-08-19 | E-GEOD-17211 | biostudies-arrayexpress
TranscriptomicsThe Prion Protein (PrP) is involved in translation via RNA granule-like mRNPs, a connection which is impaired during neurodegenerative diseases
Cytoplasmic RNA granules have emerged as important elements of posttranscriptional and translational regulation. Stress, germinal and neuronal granules contain RNA-binding proteins capable of self-assembly due to prion-like domains. Hyperassembly mediated by these prion-like domains causes several n...
ORGANISM(S): Mus musculus 
2015-11-01 | E-GEOD-57233 | biostudies-arrayexpress
MetabolomicsSMN deficiency perturbs monoamine neurotransmitter metabolism in spinal muscular atrophy

Beyond motor neuron degeneration, homozygous mutations in the survival motor neuron 1 (SMN1) gene cause multiorgan and metabolic defects in patients with spinal muscular atrophy (SMA). However, the precise biochemical features of these alterations and the age of onset in the brain and peripheral ...

2023-11-27 | MTBLS8784 | MetaboLights
TranscriptomicsscRNA-seq of aortic arches from smooth muscle cell–specific Hif1a knockout and control mice with atherosclerosis
Smooth muscle cells (SMCs) undergo phenotypic switching during atherosclerosis and give rise to a large fraction of plaque cells. To investigate the role of hypoxia-inducible factor 1α (HIF1α) signaling in SMC behaviour during atherogenesis, we used mice in which Hif1a is conditionally deleted in li...
ORGANISM(S): Mus musculus 
2026-06-21 | E-MTAB-17142 | biostudies-arrayexpress
TranscriptomicsCholesterol lowering depletes smooth muscle cell-derived fibromyocytes and chondromyocytes from atherosclerotic lesions
Study of the effect of low-density lipoprotein (LDL)-lowering therapies on the heterogeneous population of proliferating smooth muscle cells (SMCs) derived from atherosclerotic plaques in an atherosclerotic mouse model by inducing hypercholesterolemia followed by high or low fat diet.
ORGANISM(S): Mus musculus 
2023-12-08 | E-MTAB-12019 | biostudies-arrayexpress
TranscriptomicsRNA-Seq of Pseudomonas fluorescens SBW25 isolated from axenic rhizospheres of the barley varieties Chevallier and Tipple one and five days post-inoculation.
Pseudomonas fluorescens SBW25 cultures were inoculated into the rhizospheres of barley seedlings of the Chevallier and Tipple varieties growing in axenic cultures. Bacterial cells were collected from the rhizosphere one and five days after inculation and RNA extracted from them. Culture used for ino...
ORGANISM(S): Pseudomonas fluorescens SBW25 
2023-05-15 | E-MTAB-12918 | biostudies-arrayexpress
TranscriptomicsExpression analysis in hipsc-derived neurons exposed to botulinum neurotoxin A subtype 1 and a type A atoxic derivative
Transcriptome analysis of RNA extracted from human induced pluripotent stem cell (hipsc)-derived neurons exposed to botulinum neurotoxin type A1 (BoNT/A1) and an atoxic derivative, BoNT/A ad. Botulinum neurotoxin type A1 (BoNT/A1) is a potent protein toxin responsible for the potentially fatal human...
ORGANISM(S): Homo sapiens 
2014-09-15 | E-GEOD-58149 | biostudies-arrayexpress
TranscriptomicsComparison of genomic, morphological, and behavioral responses among fathead minnow (Pimephales promelas ) and zebrafish (Danio rerio) to acute RDX exposure
Paper Abstract. Extrapolating toxicological sensitivity information across species can require the use of highly conservative safety factors as prescribed by ecological risk assessment protocols. The objective of our study was to use multipule factors to understand the dynamics of stress responses ...
ORGANISM(S): Danio rerio 
2011-02-08 | E-GEOD-27067 | biostudies-arrayexpress
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