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GenomicsGenome-wide erasure of DNA methylation in mouse primordial germ cells is affected by Aid deficiency
Epigenetic reprogramming including demethylation of DNA occurs in mammalian primordial germ cells (PGCs) and in early embryos, and is important for the erasure of imprints and epimutations, and the return to pluripotency. The extent of this reprogramming and its molecular mechanisms are poorly under...
ORGANISM(S): Mus musculus 
2010-01-26 | E-GEOD-19960 | biostudies-arrayexpress
GenomicsConservation and divergence of methylation patterning in plants and animals
Cytosine DNA methylation is a heritable epigenetic mark present in many eukaryotic organisms. While DNA methylation likely has a conserved role in gene silencing, the levels and patterns of DNA methylation appear to vary drastically among different organisms. Here, we used shotgun genomic bisulfite ...
ORGANISM(S): Ciona intestinalis 
2010-04-09 | E-GEOD-21152 | biostudies-arrayexpress
GenomicsLoss of H3K27 monomethylation leads to DNA-methylation-independent release of gene silencing
Constitutive heterochromatin in Arabidopsis thaliana is marked by repressive chromatin modifications including DNA methylation, histone 3 dimethylation at lysine 9 (H3K9me2), and monomethylation at lysine 27 (H3K27me1). The enzymes catalyzing DNA methylation and H3K9me2 have been identified and muta...
ORGANISM(S): Arabidopsis thaliana 
2009-05-31 | E-GEOD-16071 | biostudies-arrayexpress
TranscriptomicsRNA-seq of Candida albicans cells of the wildtype strain SC5314 and a sky2 deletion mutant grown on different carbon sources (glucose, malic acid, succinic acid)
RNA-sequencing was performed to investigate the role of the Candida albicans protein kinase Sky2 in metabolic adaptation to alternative carbon sources. The Candida albicans wildtype strain SC5314 and a sky2 deletion mutant were grown in medium with either glucose (3h), malic acid (6h) or succinic ac...
ORGANISM(S): Candida albicans 
2026-04-01 | E-MTAB-16222 | biostudies-arrayexpress
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