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TranscriptomicsGenetic Neuropathology of Obsessive Psychiatric Syndromes
Anorexia nervosa (AN), bulimia nervosa (BN), and obsessive-compulsive disorder (OCD) are complex psychiatric disorders with shared obsessive features, thought to arise from the interaction of multiple genes of small effect with environmental factors. Potential candidate genes for AN, BN, and OCD ha...
ORGANISM(S): Homo sapiens 
2014-08-08 | E-GEOD-60190 | biostudies-arrayexpress
TranscriptomicsGenome-wide analysis of promoter methylation in pancreatic adenocarcinoma
Methylation profiles of pancreatic adenocarcinoma cell lines were compared with normal pancreatic ductal tissues Methylated CpG island amplification was followed by CpG island microarray
ORGANISM(S): Homo sapiens 
2011-06-04 | E-GEOD-29723 | biostudies-arrayexpress
TranscriptomicsTriplication of a 21q22 region contributes to B cell transformation through HMGN1 overexpression and loss of histone H3 Lys27 trimethylation [RNA-Seq]
Down syndrome (DS) confers a 20-fold increased risk of B cell acute lymphoblastic leukemia (ALL), yet the mechanisms underlying this association are undefined.  We show that triplication of only 31 genes orthologous to the putative DS Critical Region (DSCR) on chr.21q22 is sufficient to promote B ce...
ORGANISM(S): Mus musculus 
2014-04-20 | E-GEOD-48553 | biostudies-arrayexpress
GenomicsTriplication of a 21q22 region contributes to B cell transformation through HMGN1 overexpression and loss of histone H3 Lys27 trimethylation [ChIP-seq]
Children with Down syndrome (DS) have a 20-fold increased risk of developing B cell acute lymphoblastic leukemia (B-ALL). Polysomy 21 (i.e., extra copies of chr.21) is also the most frequent somatic aneuploidy among all B-ALLs. Additional B-ALLs harbor intrachromosomal amplifications of chr.21q22 (i...
ORGANISM(S): Mus musculus 
2014-04-20 | E-GEOD-48534 | biostudies-arrayexpress
UnknownIsoforms of the TAL1 transcription factor have different roles in hematopoiesis and cell growth.
Not available
S-EPMC10335695 | biostudies-literature
TranscriptomicsTE-Array-- A high throughput tool to study transposon transcription
TE-Array is a custom Agilent microarray that probes for transposable elements in both sense and antisense orientations in humans and mice. TE-Array was used to study expression levels of transposable elements (TE) in a panel of normal mouse tissues. TE-Array comprises of 4 different custom Agilent 4...
ORGANISM(S): Mus musculus 
2013-11-16 | E-GEOD-52412 | biostudies-arrayexpress
TranscriptomicsNID2 and HOXA9 promoter hypermethylation as biomarkers to prevent and detect Oral Cavity Squamous Cell Carcinoma
Differentially methylated oral squamous cell carcinoma (OSCC) biomarkers, identified in-vitro and validated in well-characterized surgical specimens, have shown poor clinical correlation in cohorts with different risk profiles. To overcome this lack of relevance we used the HumanMethylation27 BeadCh...
ORGANISM(S): Homo sapiens 
2013-02-13 | E-GEOD-28217 | biostudies-arrayexpress
ProteomicsIdentification of the SS18-SSX interacting proteins
Using affinity purification determine changes in SS18 BAF complex upon fusion to SSX1. Using soluble nuclear fraction (nuclear extract NE) and nuclease digested chromatin fraction (CHR) we performed affinity capture of proteins bound to wild type SS18 and synovial sarcoma SS18-SSX1 fusion from NE an...
ORGANISM(S): Homo sapiens (Human) 
2020-08-09 | PXD018715 | Pride
Histones Baf complex Nuclear extract 293t cells Synovial sarcoma Chromatin 
UnknownTransformation of follicular lymphoma to diffuse large B-cell lymphoma proceeds by distinct oncogenic mechanisms.
Not available
S-EPMC2532951 | biostudies-literature
GenomicsGenetic and Functional Drivers of Diffuse Large B Cell Lymphoma
Diffuse large B cell lymphoma (DLBCL) is the most common hematologic malignancy and is characterized by a striking degree of heterogeneity. We enrolled a total of 1001 DLBCL patients and comprehensively defined the landscape of genetic mutations, copy number alterations and expression through whole-...
EGAS00001002606 | EGA
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