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UnknownSafety and survival with GVAX pancreas prime and Listeria Monocytogenes-expressing mesothelin (CRS-207) boost vaccines for metastatic pancreatic cancer.
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S-EPMC4397277 | biostudies-literature
TranscriptomicsNovel Immunotherapy-Induced Tertiary Lymphoid Aggregates Accumulate as Intratumoral Nodal Structures of Immune Regulation in Pancreatic Cancer
Immunotherapy provides an alternative approach for cancer treatment. However, in-depth analyses of the effects of immunotherapy on the tumor microenvironment (TME) have not been conducted in non-melanoma tumors. Here we describe changes in the pancreatic ductal adenocarcinoma (PDAC) TME following i...
ORGANISM(S): Homo sapiens 
2014-08-05 | E-GEOD-52171 | biostudies-arrayexpress
TranscriptomicsAnnexin A2 controls pancreatic cancer invasion and metastasis through a novel axon guidance pathway
The mechanisms involved in promoting metastasis of pancreatic ductal adenocarcinoma have yet to be elucidated. Here, we show that AnnexinA2 regulates the secretion of Semaphorin3D from pancreatic tumor cells allowing it to bind to its receptor PlexinD1 on the surface of the tumor cell, which induces...
ORGANISM(S): Mus musculus 
2015-09-03 | E-GEOD-62285 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse cell lines immune sensitive P0 and immune resistant P3 identifies a tumor immune evasion mechanism using P0 and P3 cell lines
The emergence of immune resistance variants during immunotherapy is poorly understood. We generated a highly immune resistant cell line (P3) from a susceptible cell line (P0) by subjecting it to 3 rounds of in vivo immune selection. Subsequently, microarray analysis of P0 and P3 was performed to i...
ORGANISM(S): Mus musculus 
2008-06-12 | E-GEOD-2774 | biostudies-arrayexpress
ProteomicsStromal Changes in The Aged Lung Induce an Emergence From Melanoma Dormancy
Disseminated cancer cells (DCCs) that escape the primary site can seed in distal tissues, but may take several years, or even decades to grow out into overt metastases, a phenomenon termed tumor dormancy. Despite its importance in metastasis and residual disease, few studies have been able to succes...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2022-03-03 | MSV000088977 | MassIVE
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