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TranscriptomicsTranscription profiling of human umbilical vein endothelial cells (HUVEC) treated with thrombin and leukotriene D4 (LTD4) with ethanol controls to delinate Cysteinyl leukotrienes mode of action
Cysteinyl leukotrienes (cysLT), i.e. LTC4, LTD4, and LTE4, are lipid mediators derived from the 5-lipoxygenase pathway. The cysLT receptors cysLT1-R and cysLT2-R are expressed on different target cells and mediate inflammatory reactions in tissue- and LT-R-specific ways. Though endothelial cells (EC...
ORGANISM(S): Homo sapiens 
2007-10-27 | E-GEOD-3589 | biostudies-arrayexpress
ProteomicsProteogenomic pathogenesis and classification of acute myeloid leukemia
Acute myeloid leukemia is a clinically and genetically heterogenous disease characterized by bone marrow infiltration with immature leukemic blasts that cause bone marrow failure. Patient age, comorbidities and genomic disease characteristics have a profound impact on patient outcome. Here, we prese...
ORGANISM(S): Homo sapiens (Human) 
2022-03-08 | PXD022894 | Pride
Transcriptome Mitochondria Proteome Acute myeloid leukemia 
ProteomicsProteogenomic pathogenesis and classification of acute myeloid leukemia
Acute myeloid leukemia is a clinically and genetically heterogenous disease characterized by bone marrow infiltration with immature leukemic blasts that cause bone marrow failure. Patient age, comorbidities and genomic disease characteristics have a profound impact on patient outcome. Here, we prese...
ORGANISM(S): Homo sapiens (Human) 
2022-03-08 | PXD023090 | Pride
Supersilac Proteome Aml 
ProteomicsThe Proteogenomic Subtypes of Acute Myeloid Leukemia
Acute myeloid leukemia (AML) is an aggressive blood cancer with poor prognosis. We performed a comprehensive proteogenomic analysis of bone-marrow biopsies from 252 uniformly treated AML patients to elucidate the molecular pathophysiology of AML in order to inform future diagnostic and therapeutic a...
ORGANISM(S): Homo sapiens (Human) 
2022-03-08 | PXD028007 | Pride
Acute myeloid leukemia Healthy controls Proteome Cd34 cells 
ProteomicsProteogenomic pathogenesis and classification of acute myeloid leukemia (Discovery cohort)
Acute myeloid leukemia is a clinically and genetically heterogenous disease characterized by bone marrow infiltration with immature leukemic blasts that cause bone marrow failure. Patient age, comorbidities and genomic disease characteristics have a profound impact on patient outcome. Here, we prese...
ORGANISM(S): Homo sapiens (Human) 
2022-03-08 | PXD023201 | Pride
Aml Dia Label free proteome 
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