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TranscriptomicsArray-based comparative genomic hybridization analysis of primary neuroblastoma
We conducted microarray-based comparative genomic hybridization (array-CGH) with a DNA chip carrying 2,464 BAC clones to examine genomic aberrations of 236 neuroblastomas (112 sporadic and 124 mass screening-detected). In paralell, gene-expression profiling was also performed by using in-house cDNA ...
ORGANISM(S): Homo sapiens 
2007-08-06 | E-GEOD-5784 | biostudies-arrayexpress
TranscriptomicsA high resolution map of a cyanobacterial transcriptome
Previous molecular and mechanistic studies have identified several principles of prokaryotic transcription, but less is known about the global transcriptional architecture of bacterial genomes. Here we perform a comprehensive study of a cyanobacterial transcriptome, that of Synechococcus elongatus P...
ORGANISM(S): Synechococcus elongatus PCC 7942 
2011-05-16 | E-GEOD-29264 | biostudies-arrayexpress
ProteomicsDefining albumin as a glycoprotein with multiple N-linked glycosylation sites
Background Plasma proteins can be modified by addition of sugar residues by non-enzymatic glycation as well as glycosylation. While glycation is a hallmark of hyperglycemia, glycosylation is a complex, enzyme-catalyzed post-translational modification by heterogeneous sugar chains and is present on ...
ORGANISM(S): Bos taurus (Bovine) Homo sapiens (Human) Oryctolagus cuniculus (Rabbit) 
2024-06-16 | PXD047863 | Pride
Microheterogeneity Glycoproteomics Novel glycosylation site Hsa Human serum albumin Bsa 
MetabolomicsA polyamine-centric blood-based metabolite panel predictive of poor response to CAR T-cell therapy in large B cell lymphoma

Anti-CD19 chimeric antigen receptor (CAR) T-cell therapy for relapsed or refractory (r/r) large B-cell lymphoma (LBCL) results in durable response in only a subset of patients. MYC overexpression in LBCL tumors is associated with poor response to treatment. We tested whether a MYC-driven polyamin...

2022-10-31 | MTBLS5381 | MetaboLights
MetabolomicsA pathogen-specific isotope tracing approach reveals metabolic activities and fluxes of intracellular Salmonella

Pathogenic bacteria proliferating inside mammalian host cells need to rapidly adapt to the intracellular environment. How they achieve this and scavenge essential nutrients from the host has been an open question due to the difficulties in distinguishing between bacterial and host metabolites

2023-08-02 | MTBLS1275 | MetaboLights
UnknownAbsence of BTK, BCL2, and PLCG2 Mutations in Chronic Lymphocytic Leukemia Relapsing after First-Line Treatment with Fixed-Duration Ibrutinib plus Venetoclax.
Not available
S-EPMC10831330 | biostudies-literature
UnknownBiolytic extraction of poly(3-hydroxybutyrate) from Bacillus megaterium Ti3 using the lytic enzyme of Streptomyces albus Tia1.
Not available
S-EPMC6354000 | biostudies-literature
ProteomicsUrinary Glycoproteomic profiling of Non-Muscle Invasive and Muscle Invasive Bladder Carcinoma Patients reveals distinct N-glycosylation pattern of CD44, MGAM and GINM1
Clinical management of bladder carcinomas (BC) remains a major challenge and demands comprehensive multi-omics analysis for better stratification of the disease. Identification of patients on risk requires identification of signatures predicting prognosis risk of the patients. Understanding the mole...
ORGANISM(S): Homo sapiens (Human) 
2020-09-10 | PXD020078 | Pride
Urothelial carcinoma  n-linked glycoproteomics  urine proteomics  nmibc  mibc 
UnknownReaction of unsymmetrical α-bromo-1,3-diketones with N-substituted thioureas: regioselective access to 2-(N-arylamino)-5-acyl-4-methylthiazoles and/or rearranged 2-(N-acylimino)-3-N-aryl-4-methylthiazoles.
Not available
S-EPMC11544347 | biostudies-literature
GenomicsEndogenous DAF-16 genome-wide recruitment under low Insulin signaling condition in Caenorhabditis elegans
In order to understand the complexity of gene regulation downstream of IIS, we used anti-DAF-16 antibody, we report the first genome-wide ChIP-sequencing study of endogenous DAF-16 recruitment in daf-2(e1370). We also report the average bin-wise normalized read count of ZFP-1 and DAF-16 on DAF-16 s...
ORGANISM(S): Caenorhabditis elegans 
2016-03-01 | E-GEOD-63865 | biostudies-arrayexpress
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