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ProteomicsMutant JAK3 phosphoproteomic profiling predicts synergism between JAK3 inhibitors and MEK/PI3K/BCL2 inhibitors for the treatment of T-cell acute lymphoblastic leukemia
Mutations in the interleukin-7 receptor (IL7R) or the JAK3 kinase occur frequently in T-cell acute lymphoblastic leukemia (T-ALL) and both are able to drive cellular transformation and the development of T-ALL in mouse models. However, the signal transduction pathways downstream of JAK3 mutations re...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) Mus Musculus (ncbitaxon:10090) 
2017-07-14 | MSV000081327 | MassIVE
GenomicsPolynucleobacter yangtzensis strain:MWH-JaK3
Polynucleobacter MWH-JaK3 Genome sequencing
PRJNA277963 | ENA
GenomicsEndothelial Jak3 expression enhances pro-hematopoietic angiocrine function
Endothelial Jak3 expression enhances pro-hematopoietic angiocrine function
PRJNA670425 | ENA
TranscriptomicsExpression data from NKYS transfected with siRNAs or plasmids
The siRNA transfection includes JAK3 and EZH2 siRNAs. The plasmid transfection includes EZH2 WT and its mutants. We used gene expression data from JAK3 siRNA to test whether it affected epigenetic regulation, and used EZH2 mutants to study how it affected EZH2 canonical function. Whole genome microa...
ORGANISM(S): Homo sapiens 
2016-07-26 | E-GEOD-75680 | biostudies-arrayexpress
TranscriptomicsEndothelial Jak3 expression enhances pro-hematopoietic angiocrine function
Jak3 is the only non-promiscuous member of the Jak family of secondary messengers. Jak3–/– mice display defective T and NK cell development, which results in a SCID phenotype. As a result, studies to date have focused on understanding and targeting the cell-autonomous role of Jak3 in immunity, while...
ORGANISM(S): Mus musculus 
2021-10-20 | GSE159755 | GEO
UnknownMutant JAK3 signaling is increased by loss of wild-type JAK3 or by acquisition of secondary JAK3 mutations in T-ALL.
Not available
S-EPMC5796683 | biostudies-literature
UnknownTubulosine selectively inhibits JAK3 signalling by binding to the ATP-binding site of the kinase of JAK3.
Not available
S-EPMC7339168 | biostudies-literature
GenomicsPRC2 inactivation cooperates with JAK3 mutant signaling in the development of T-cell acute lymphoblastic leukemia
PRC2 inactivation cooperates with JAK3 mutant signaling in the development of T-cell acute lymphoblastic leukemia
PRJNA505355 | ENA
UnknownDifferential regulation of Janus kinase 3 (JAK3) in bovine preovulatory follicles and identification of JAK3 interacting proteins in granulosa cells.
Not available
S-EPMC5086056 | biostudies-literature
UnknownIdentification of U937JAK3-M511I Acute Myeloid Leukemia Cells as a Sensitive Model to JAK3 Inhibitor.
Not available
S-EPMC8802890 | biostudies-literature
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