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TranscriptomicsTranscription profiling of human cell lines K562, Me45 and HCT116 with or without p53 knock-out to study the effect of ionizing radiation
The objective of the experiment was to compare changes in the transcriptome induced by direct X-irradiation of cells, using the human K562 erythroleukemic, Me45 melanoma and HCT116 colon cancer cell lines. The transcript levels of K542 and Me45 RNA samples were measured using Affymetrix HG-U133A mic...
ORGANISM(S): Homo sapiens 
2010-09-28 | E-MEXP-2623 | biostudies-arrayexpress
TranscriptomicsSmall RNA-Seq Reveals similar miRNA Transcriptome in Children and Young Adults with T-ALL and Indicates miR-143-3p as Novel Candidate Tumor Suppressor in This Leukemia
We aimed to identify miRNAs and pathways specifically deregulated in adolescent and young adult (AYA) T-ALL patients. Small RNA-seq showed no major differences between AYA and pediatric T-ALL, but it revealed downregulation of miR-143-3p in T-ALL patients. Prediction algorithms identified several kn...
ORGANISM(S): Homo sapiens 
2022-09-06 | E-MTAB-11987 | biostudies-arrayexpress
TranscriptomicsSearching for the fusion transcripts created during proteotoxic stress
To verify the hypothesis that proteotoxic stress induces the formation of fusion transcripts in non-cancerous and cancerous cells derived from breast epithelium, we exposed the cells to heat shock (HS, 1h at 43 degrees). We selected MCF10A non-tumorigenic breast epithelial cells (isolated from the m...
ORGANISM(S): Homo sapiens 
2024-12-01 | E-MTAB-13903 | biostudies-arrayexpress
TranscriptomicsComprehensive investigation of miRNome identifies novel candidate miRNA-mRNA interactions implicated in T-cell acute lymphoblastic leukemia
The aim of the study was to characterize the landscape of miRNA expression in 34 samples of pediatric T-cell acute lymphoblastic leukemia (T-ALL) and to identify miRNAs differentially expressed between T-ALL and normal mature T lymphocytes (5 samples).
ORGANISM(S): Homo sapiens 
2019-01-28 | E-MTAB-7446 | biostudies-arrayexpress
TranscriptomicsTranscriptional responses to TGFβ1 and conditioned media in mammary epithelial cells
To investigate TGFβ1 (a key member of the TGFβ superfamily) signaling in non-cancerous and cancerous cells derived from breast epithelium and what further response it might generate, we treated the cells with TGFβ1 or with conditioned media. We selected MCF10A non-tumorigenic breast epithelial cells...
ORGANISM(S): Homo sapiens 
2024-12-01 | E-MTAB-13865 | biostudies-arrayexpress
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