Sort   by:  
 Page size 
TranscriptomicsRNA-seq as a global measure of the similarity between human pluripotent stem cell and fetal liver derived B cell hierarchies
Evidence suggests childhood acute lymphoblastic leukemia (cALL) arises in early human development. Existing models of pre-leukemic initiation using the ETV6-RUNX1 fusion do not recapitulate human disease, highlighting the need for a developmentally relevant human model system. A human pluripotent st...
ORGANISM(S): Homo sapiens 
2018-02-08 | E-MTAB-6382 | biostudies-arrayexpress
TranscriptomicsMir142 loss unlocks IDH2R140-dependent leukemogenesis through antagonistic regulation of HOX genes
Acute myeloid leukaemia (AML) is genetically a genetically heterogeneous condition. It was observed that mutations in the micro RNA mir142 co-occurred with mutations in isocitrate dehdrogenase genes IDH1 and 2. These experiments intend to investigate the interaction between miR142 and IDH in AML.
ORGANISM(S): Mus musculus 
2020-06-05 | E-MTAB-8042 | biostudies-arrayexpress
TranscriptomicsRNA-seq to assess the impact of circulation on hematopoietic stem cell differentiation.
Blood flow promotes hematopoiesis, Definitive hematopoietic stem cells can not be assessed in circulation negative Ncx-/- mice. This study looks at the impact of lack of blood flow on the earliest blood cell precursors, the pro-HSCs. E9.5 was chosen as this is the time point pro-HSCs are normally ...
ORGANISM(S): Mus musculus 
2021-10-01 | E-MTAB-8362 | biostudies-arrayexpress
GenomicsTracking of barcodes introduced in the genomes of HCC827 cell populations over time under high doses of gefitinib and trametinib
HCC827 cells were barcoded using the ClonTracer lentiviral barcode library such that the majority of cells were infected with a single barcode. One million cells were expanded to ~120 million cells and split into 8 HYPERfasks. Two HYPERfasks were grown under DMSO and grown until confluence. In six H...
ORGANISM(S): Homo sapiens 
2020-08-18 | E-MTAB-8841 | biostudies-arrayexpress
TranscriptomicsExploiting evolutionary steering to induce collateral drug sensitivity in cancer
This study contains single cell RNA-seq of the non-small cell lung cancer line HCC827 in three conditions. Firstly we have sequenced the RNA of single cells of a culture of HCC827 cells grown in normal conditions (POT). In our study we then evolved two arms of the cell line, one in the presence of t...
ORGANISM(S): Homo sapiens 
2020-08-18 | E-MTAB-8809 | biostudies-arrayexpress
TranscriptomicsRNA-seq analysis of substates of human pluripotent stem cells with mesoderm bias and early differentiating cells towards the mesoderm lineage
The differentiation of human pluripotent stem cells (hPSC) towards clinically relevant cells for regenerative medicine has been hampered by poor differentiation efficiencies. This may be a result, in part, of the heterogeneity that exists within stem cell cultures. We have generated a new stem cell ...
ORGANISM(S): Homo sapiens 
2020-08-31 | E-MTAB-9474 | biostudies-arrayexpress
Sort   by:  
 Page size