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TranscriptomicsTranscription profiling of mouse liver from JNK knocked down animals
Liver-specific Knockdown of JNK1 Up-regulates Proliferator-activated Receptor Coactivator 1 and Increases Plasma Triglyceride despite Reduced Glucose and Insulin Levels in Diet-induced Obese Mice. The c-Jun N-terminal kinases (JNKs) have been implicated in the development of insulin resistance, dia...
ORGANISM(S): Mus musculus 
2008-06-15 | E-GEOD-7648 | biostudies-arrayexpress
UnknownSIRT1 Controls Acetaminophen Hepatotoxicity by Modulating Inflammation and Oxidative Stress.
Not available
S-EPMC9545809 | biostudies-literature
TranscriptomicsTotal and cholera toxin B-tetramer specific T cells from Peyer's patches and mesenteric lymph nodes
T cells were separately isolated from MLN and PP from two naive mice, and T cells binding to a cholera toxin B subunit specific MHC II tetramer from mice orally immunized with cholera toxin 7 days or boosted 5 days with a second dose of cholera toxin. Cells were purified using flow cytometric cell s...
ORGANISM(S): Mus musculus 
2022-06-22 | E-MTAB-11805 | biostudies-arrayexpress
TranscriptomicsTranscription profiling by array of acute and chronic atopic dermatitis compared to normal skin
Atopic dermatitis (AD) is a common disease, with an increasing prevalence. The primary pathogenesis of the disease is still elusive, resulting in lack of specific treatments. The prevailing view is that AD is a biphasic, T-cell polarized disease, with Th2 predominating acute AD, and a switch to Th1 ...
ORGANISM(S): Homo sapiens 
2012-09-21 | E-GEOD-36842 | biostudies-arrayexpress
TranscriptomicsRelief of feedback inhibition of HER3 transcription by RAF and MEK inhibitors attenuates their antitumor effects in BRAF mutant thyroid carcinomas.
Analysis of transcriptome kinetics of SW1736 thyroid cancer cell line vs SK-MEL-28 melanoma cell line at various times after addition of 2 µM vemurafenib. The hypothesis tested was that SW1736 cells (vemurafenib-refractory) differentially express genes compared to SK-MEL-28 cells (vemurafenib sensit...
ORGANISM(S): Homo sapiens 
2013-02-01 | E-GEOD-37441 | biostudies-arrayexpress
ProteomicsEvaluation of differential peptide loading on TMT-based proteomic and phosphoproteomic data quality
Investigating the impacts on MS data quantitation reproducibility when loading differential amounts of peptides, ranging from 20 to 400 ug, across channels of TMT 11 multiplexes. PTRC_Exp9 files represent global proteome and phosphoproteome data generated from PBMCs isolated from AML patients, acqui...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2020-11-05 | MSV000086417 | MassIVE
TranscriptomicsNovel kinase fusion oncogenes in post-Chernobyl radiation-induced pediatric thyroid cancers
Exposure to ionizing radiation during childhood markedly increases the risk of developing papillary thyroid cancer. We identified non-overlapping somatic driver mutations in all 26 cases of post-Chernobyl thyroid cancers we studied through candidate gene assays and next generation RNA-sequencing. We...
ORGANISM(S): Homo sapiens 
2013-10-25 | E-GEOD-48850 | biostudies-arrayexpress
UnknownThe Medical Genome Reference Bank contains whole genome and phenotype data of 2570 healthy elderly.
Not available
S-EPMC6978518 | biostudies-literature
ModelsNeves2008 - Role of cell shape and size in controlling intracellular signalling
Neves2008 - Role of cell shape and size in controlling intracellular signalling The role of cell shape and size in the flow of spatial information from the cell surface receptor to downstream components within the cell has been studied on the β-adrenergic receptor to MAPK-signallin...
2024-09-02 | BIOMD0000000182 | BioModels
TranscriptomicsTET2 mutations are associated with specific methylation profiles in patients with Chronic Myelomonocytic Leukemia
Chronic myelomonocytic leukemia (CMML) has recently been associated with a high incidence of diverse mutations in genes implicated in epigenetic mechanisms such as TET2 or EZH2. We have performed genome-wide methylation arrays and mutational analysis of TET2, IDH1, IDH2, EZH2 and JAK2 in a group of ...
ORGANISM(S): Homo sapiens 
2012-02-13 | E-GEOD-31600 | biostudies-arrayexpress
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