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ProteomicsPhosphoproteomic analysis reveals enhanced PKA signaling in aged skeletal muscle is suppressed by caloric restriction
Although caloric restriction (CR) was first shown to extend the lifespan of rodents over 75 years ago, the underlying mechanisms remain unclear. Additionally, the majority of published studies have focused on the effects of short-term CR. To better understand cell signaling alterations in a tissue k...
ORGANISM(S): Mus Musculus (mouse) 
2021-01-30 | PXD018455 | JPOST Repository
ProteomicsIdentification of regulators of polyploidization presents therapeutic targetsfor treatment of AMKL
Wen Q, Goldenson B, Silver SJ, Schenone M, Dancik V, Huang Z, Wang LZ, Lewis TA, An WF, Li X, Bray MA, Thiollier C, Diebold L, Gilles L, Vokes MS, Moore CB, Bliss-Moreau M, Verplank L, Tolliday NJ, Mishra R, Vemula S, Shi J, Wei L, Kapur R, Lopez CK, Gerby B, Ballerini P, Pflumio F, Gilliland DG, Go...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2014-01-27 | MSV000078536 | MassIVE
MetabolomicsMetabolomics-derived insights into the manipulation of terpenoid sysnthesis in Centella asiatica cells by methyl-jasmonate
Centella asiatica is an important medicinal plant with a wide range of bioactivities associated with its secondary metabolites. Using two extraction procedures, metabolomic approaches were used to investigate changes in the metabolome of C. asiatica cells treated with exogenous MeJA. GC–MS and LC–MS...
2015-03-03 | MTBLS175 | MetaboLights
ProteomicsComprehensive respiratory phenomics across multiple models of mitochondrial protein hyperacylation reveals a paradoxically marginal impact on bioenergetics
Acyl CoA metabolites derived from catabolism of carbon fuels can react with lysine residues of mitochondrial proteins, giving rise to a large family of post-translation modifications (PTMs). Mass spectrometry-based detection of thousands of acyl-PTMs scattered throughout the proteome has established...
ORGANISM(S): Mus Musculus (mouse) 
2019-02-07 | PXD011375 | JPOST Repository
ProteomicsProteomics, post-translational modifications, and integrative analyses reveal heterogeneity of molecular mechanisms within medulloblastoma subgroups
Archer TC, Ehrenberger T, Mundt F, Gold MP, Krug K, Mah CK, Mahoney EL, Daniel CJ, LeNail A, Ramamoorthy D, Mertins P, Mani DR, Zhang H, Gillette MA, Clauser K, Noble M, Tang LC, Francois JP, Silterra J, Jensen J, Tamayo P, Korshunov A, Pfister SM, Kool M, Northcott PA, Sears RC, Lipton JO, Carr SA,...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2018-07-20 | MSV000082644 | MassIVE
UnknownUnderstanding API Static Drying with Hot Gas Flow: Design and Test of a Drying Rig Prototype and Drying Modeling Development.
Not available
S-EPMC7685224 | biostudies-literature
UnknownPhase I trial and pharmacokinetic study of lexatumumab in pediatric patients with solid tumors.
Not available
S-EPMC3494837 | biostudies-literature
UnknownDefinitive results of a phase III adjuvant trial comparing three chemotherapy regimens in women with operable, node-positive breast cancer: the NSABP B-38 trial.
Not available
S-EPMC3757290 | biostudies-literature
UnknownImpact of Surveillance Imaging Modality on Survival After Recurrence in Patients With Favorable-Histology Wilms Tumor: A Report From the Children's Oncology Group.
Not available
S-EPMC6269130 | biostudies-literature
TranscriptomicsEffect of HE4 overexpression or treatment with recombinant HE4 protein on OVCAR8 ovarian cancer cells
The ovarian cancer biomarker HE4 has been shown to have multiple effects on ovarian cancer pathogenesis. In order to reveal gene regulation upstream of HE4 biological effects in ovarian cancer, HE4 was overexpressed in OVCAR8 wild type ovarian cancer cells and compared to null vector transfected cel...
ORGANISM(S): Homo sapiens 
2018-01-15 | E-MTAB-6366 | biostudies-arrayexpress
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