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MetabolomicsMitochondrial metabolism sustains DNMT3A-R882-mutant clonal haematopoiesis
Somatic DNMT3A R882 codon mutations drive the most common form of clonal haematopoiesis (CH) and are associated with increased acute myeloid leukaemia (AML) risk1,2. Preventing expansion of DNMT3A-R882-mutant haematopoietic stem/progenitor cells (HSPCs) may therefore avert progression to AML. To ide...
2025-02-06 | MTBLS12201 | MetaboLights
TranscriptomicsTranscription profiling of Arabidopsis to investigate protective role of silicon in the Arabidopsis-powdery mildew pathosystem
The role and essentiality of silicon (Si) in plant biology has been debated for over 150 years in spite of numerous reports describing its beneficial properties. To obtain unique insights regarding the effect of Si on plants, we performed a complete transcriptome analysis of both control and powdery...
ORGANISM(S): Arabidopsis thaliana 
2008-06-14 | E-GEOD-5718 | biostudies-arrayexpress
UnknownSingle agent BMS-911543 Jak2 inhibitor has distinct inhibitory effects on STAT5 signaling in genetically engineered mice with pancreatic cancer.
Not available
S-EPMC4792572 | biostudies-literature
TranscriptomicsH2-ab1 Mouse Parent of Origin
We looked for parent of origin effects on genome-wide gene expression in a reciprocal cross between C57BL/6J x B6(C)-H2bm12/KhEgJ mice (the latter strain is a knockout of H2-ab1 on a C57BL/6J background). The aim is to find genes whose expression is altered in trans depending on whether the mother o...
ORGANISM(S): Mus musculus 
2013-11-01 | E-MTAB-1998 | biostudies-arrayexpress
UnknownInhibiting BRAF Oncogene-Mediated Radioresistance Effectively Radiosensitizes BRAFV600E-Mutant Thyroid Cancer Cells by Constraining DNA Double-Strand Break Repair.
Not available
S-EPMC6677585 | biostudies-literature
UnknownHuman Vγ2Vδ2 T cells limit breast cancer growth by modulating cell survival-, apoptosis-related molecules and microenvironment in tumors.
Not available
S-EPMC3939063 | biostudies-literature
TranscriptomicsClinically Relevant Copy Number Variations Detected in Cerebral Palsy
Cerebral palsy (CP) represents a group of non-progressive clinically heterogeneous disorders that are characterized by motor impairment and early age-of-onset, frequently accompanied by co-morbidities. The cause of CP has historically been attributed to environmental stressors resulting in brain dam...
ORGANISM(S): Homo sapiens 
2015-07-28 | E-GEOD-70374 | biostudies-arrayexpress
UnknownCaveolae-Mediated Endocytosis Is Critical for Albumin Cellular Uptake and Response to Albumin-Bound Chemotherapy.
Not available
S-EPMC5668166 | biostudies-literature
UnknownSingle-Isocenter Multitarget Stereotactic Radiosurgery Is Safe and Effective in the Treatment of Multiple Brain Metastases.
Not available
S-EPMC7004936 | biostudies-literature
UnknownComparison of microRNA deep sequencing of matched formalin-fixed paraffin-embedded and fresh frozen cancer tissues.
Not available
S-EPMC3655971 | biostudies-literature
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