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ProteomicsHigh-field asymmetric waveform ion mobility spectrometry interface enhances parallel reaction monitoring on an Orbitrap mass spectrometer
High-field asymmetric waveform ion mobility spectrometry (FAIMS) enables gas phase separations on a chromatographic timescale and has become a useful tool for proteomic applications. Despite its emerg-ing utility, however, the molecular determinants underlying peptide separation by FAIMS have not be...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2022-03-07 | MSV000089014 | MassIVE
ProteomicsMYCT1 CONTROLS ENVIRONMENTAL SENSING IN HUMAN HEMATOPOIETIC STEM CELLS
Hematopoietic stem cells (HSC) rely on a unique regulatory machinery that facilitates life-long blood production and enables reconstitution of the entire hematopoietic system upon transplantation. However, the biological processes governing human HSC self-renewal and engraftment ability are poorly u...
ORGANISM(S): Homo sapiens (Human) 
2024-04-15 | PXD042257 | Pride
Myct1 Proteomics Stem cells 
ProteomicsAstrocyte and neuron cell surface proteomes
We developed, tested and validated a method to determine the cell surface proteomes (CSPs) of striatal astrocytes and neurons. We used this method to study the CSPs and how they change in mouse models of disorders that affect the striatum. We compared our data to postmortem human data to identify di...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2024-02-20 | MSV000094132 | MassIVE
ProteomicsDynamic Assembly of the Cytosolic Iron-Sulfur Cluster Biogenesis Machinery Requires Iron-Sulfur Cluster Incorporation of CIAO3
Cytosolic iron-sulfur (Fe-S) cluster assembly (CIA) pathway delivers Fe-S clusters to nuclear and cytosolic Fe-S proteins involved in essential cellular functions. This delivery process is regulated by availability of iron and oxygen, but it remains unclear how CIA components orchestrate the cluster...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2021-11-16 | MSV000088394 | MassIVE
ProteomicsIron-Regulated Assembly of the Cytosolic Iron-Sulfur Cluster Biogenesis Machinery
The cytosolic iron-sulfur (Fe-S) cluster assembly (CIA) pathway delivers Fe-S clusters to nuclear and cytosolic Fe-S proteins involved in essential cellular functions. Although the delivery process is regulated by the availability of iron and oxygen, it remains unclear how CIA components orchestrate...
ORGANISM(S): Homo Sapiens 
2022-06-06 | PXD033557 | panorama
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