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UnknownBacteroides eggerthii ameliorates metabolic dysfunction-associated steatotic liver disease through host-microbe signaling and highlights 2-hydroxyisocaproate as a potential effector.

Background/aims

Gut microbiome plays a pivotal role in metabolic dysfunction-associated steatotic liver disease (MASLD) pathogenesis, yet, associated functional mechanisms and host responses of specific microbial species remain insufficiently characterized. This study investigated the Bacter...
S-EPMC12835788 | biostudies-literature
UnknownSerum Extracellular Vesicle-Associated GULP1 Is a Key Indicator of Hepatocellular Carcinoma.

Objectives

Early detection of hepatocellular carcinoma (HCC) is a significant challenge due to the limited sensitivity of alpha-fetoprotein (AFP). This study aimed to assess serum-derived extracellular vesicle-encapsulated GULP PTB domain-containing engulfment adaptor 1 (EV-GULP1) as ...
S-EPMC12848681 | biostudies-literature
UnknownIdentification of somatic mutations in EGFR/KRAS/ALK-negative lung adenocarcinoma in never-smokers.

Background

Lung adenocarcinoma is a highly heterogeneous disease with various etiologies, prognoses, and responses to therapy. Although genome-scale characterization of lung adenocarcinoma has been performed, a comprehensive somatic mutation analysis of EGFR/KRAS/ALK-negative lung adenocarci...
S-EPMC3979047 | biostudies-literature
Genomicsena-DATASET-asan-ccgd-27-09-2019-00:22:21:191-59 - samples
231 HCC exome sequencing with Sureselect 50Mb
EGAD00001005361 | EGA
GenomicsThese are from Korean HCC samples with exome sequencing
Hepatic resection is the most curative treatment option for early-stage hepatocellular carcinoma, but is associated with a high recurrence rate, which exceeds 50% at 5 years after surgery. Understanding the genetic basis of hepatocellular carcinoma at surgically curable stages may enable the identif...
EGAS00001000604 | EGA
Genomicswhole exome sequencing of Korean hepatocellular carcinomas
Data Access Committee EGAC00001000329
EGAC00001000329 | EGA
GenomicsA high dimensional deep sequencing study of non-small cell lung adenocarcinoma in never-smoker Korean females [Seq]
One of the most fertile applications of next generation sequencing will be in the field of cancer genomics. Here, we report a high-throughput multi-dimensional sequencing study of primary non-small cell lung adenocarcinoma tumors and adjacent normal tissues of 6 never-smoker Korean female patients. ...
ORGANISM(S): Homo sapiens 
2013-05-10 | E-GEOD-37764 | biostudies-arrayexpress
TranscriptomicsA high dimensional deep sequencing study of non-small cell lung adenocarcinoma in never-smoker Korean females [aCGH]
One of the most fertile applications of next generation sequencing will be in the field of cancer genomics. Here, we report a high-throughput multi-dimensional sequencing study of primary non-small cell lung adenocarcinoma tumors and adjacent normal tissues of 6 never-smoker Korean female patients. ...
ORGANISM(S): Homo sapiens 
2013-05-10 | E-GEOD-37759 | biostudies-arrayexpress
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