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UnknownTherapeutic Efficacy of Artificial Skin Produced by 3D Bioprinting.
The skin protects the body from external barriers. Certain limitations exist in the development of technologies to rapidly prepare skin substitutes that are therapeutically effective in surgeries involving extensive burns and skin transplantation. Herein, we fabricated a structure similar to the ski...
S-EPMC8467964 | biostudies-literature
Genomics97dd9532-0482-4bf1-ad1d-fb976b8ed7ea - samples
This dataset contains whole-genome sequencing data files from colon organoid cultures, which were mutated using CRISPR-Cas9 for specific genes (APC, KRAS, TP53 and SMAD4) to generate in vitro transformed cancer cells. After introducing each mutation, the resulting cultures were subjected to whole-ge...
EGAD00001002719 | EGA
GenomicsWhole genome sequencing of colon organoid cultures with artificially induced oncogenic mutations
Using the CRISPR-Cas9 genome editing system, various oncogenic mutations were introduced in the genome of normal adult stem cells derived from the colon. The resulting clonal cultures were subjected to whole genome sequencing. In addition, the cultures were transplanted in a mouse and the resulting ...
EGAS00001001969 | EGA
GenomicsDivision of Biomedical Genetics UMC Utrecht
Data Access Committee EGAC00001000432
EGAC00001000432 | EGA
Genomicsena-DATASET-asan-ccgd-27-09-2019-00:22:21:191-59 - samples
231 HCC exome sequencing with Sureselect 50Mb
EGAD00001005361 | EGA
GenomicsThese are from Korean HCC samples with exome sequencing
Hepatic resection is the most curative treatment option for early-stage hepatocellular carcinoma, but is associated with a high recurrence rate, which exceeds 50% at 5 years after surgery. Understanding the genetic basis of hepatocellular carcinoma at surgically curable stages may enable the identif...
EGAS00001000604 | EGA
Genomicswhole exome sequencing of Korean hepatocellular carcinomas
Data Access Committee EGAC00001000329
EGAC00001000329 | EGA
UnknownMesenchymal stem cells prevent the progression of diabetic nephropathy by improving mitochondrial function in tubular epithelial cells.
The administration of mesenchymal stem cells (MSCs) was shown to attenuate overt as well as early diabetic nephropathy in rodents, but the underlying mechanism of this beneficial effect is largely unknown. Inflammation and mitochondrial dysfunction are major pathogenic factors in diabetic nephropath...
S-EPMC6802630 | biostudies-literature
UnknownCyclase-associated protein 1 is a binding partner of proprotein convertase subtilisin/kexin type-9 and is required for the degradation of low-density lipoprotein receptors by proprotein convertase subtilisin/kexin type-9.

Aims

Proprotein convertase subtilisin/kexin type-9 (PCSK9), a molecular determinant of low-density lipoprotein (LDL) receptor (LDLR) fate, has emerged as a promising therapeutic target for atherosclerotic cardiovascular diseases. However, the precise mechanism by which PCSK9 regulates the in...
S-EPMC6945527 | biostudies-literature
GenomicsICGC breast cancer sequencing project SNP6 data
Affymetrix SNP6.0 breast cancer genome sequencing data
EGAD00010000915 | EGA
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