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TranscriptomicsPolycomb repressive complex 2-dependent and M-bM-^@M-^Sindependent functions of Jarid2 in transcriptional regulation in Drosophila [Affymetrix]
Jarid2 was recently identified as an important component of the mammalian Polycomb Repressive Complex 2 (PRC2), where it has a major effect on PRC2 recruitment in mouse embryonic stem cells. Although Jarid2 is conserved in Drosophila, it has not previously been implicated in Polycomb (Pc) regulation...
ORGANISM(S): Drosophila melanogaster 
2012-02-23 | E-GEOD-36038 | biostudies-arrayexpress
TranscriptomicsPolycomb repressive complex 2-dependent and M-bM-^@M-^Sindependent functions of Jarid2 in transcriptional regulation in Drosophila
This SuperSeries is composed of the following subset Series: GSE33546: Polycomb repressive complex 2-dependent and M-bM-^@M-^Sindependent functions of Jarid2 in transcriptional regulation in Drosophila [ChIP-Seq] GSE36038: Polycomb repressive complex 2-dependent and M-bM-^@M-^Sindependent functions ...
ORGANISM(S): Drosophila melanogaster 
2012-02-23 | E-GEOD-36039 | biostudies-arrayexpress
GenomicsGenome wide mapping of Jarid2 and Suz12 binding sites in mouse ES cells before and after Jarid2 depletion
We analyzed the overlap in genome wide binding sites between Jarid2 and Suz12 in mouse ES cells and find that Jarid2 and Suz12 peaks have an high degree (90%) of overlap. Moreover we analyzed the effect of Jarid2 down regulation on genome wide Suz12 binding sites and found that Loss of Jarid2 lead t...
ORGANISM(S): Mus musculus 
2010-01-27 | E-GEOD-19365 | biostudies-arrayexpress
GenomicsAnalysis of the recruitment of JARID2 via Xist RNA during XCI by ChIP-seq
JARID2 ChIP-seq profile mediated by Xist was investigated using two separate approaches: In the first approach, we use the TX1072 female embryonic stem cell (ESC) line; this is a genetically polymorphic ESC line derived from a mouse with one X-chromosome (X-chr) from the Mus musculus castaneus (Cast...
ORGANISM(S): Mus musculus 
2014-01-23 | E-GEOD-52073 | biostudies-arrayexpress
GenomicsPolycomb repressive complex 2-dependent and -independent functions of Jarid2 in transcriptional regulation in Drosophila [ChIP-Seq]
Jarid2 was recently identified as an important component of the mammalian Polycomb Repressive Complex 2 (PRC2), where it has a major effect on PRC2 recruitment in mouse embryonic stem cells. Although Jarid2 is conserved in Drosophila, it has not previously been implicated in Polycomb (Pc) regulation...
ORGANISM(S): Drosophila melanogaster 
2012-02-23 | E-GEOD-33546 | biostudies-arrayexpress
GenomicsJarid2 and PRC2, Partner in Regulating Gene Expression
The Polycomb Group proteins foster gene repression profiles required for proper development and unimpaired adulthood, and comprise the components of the PRC2 complex including the histone H3 lysine 27 (H3K27) methyltransferase Ezh2. How mammalian PRC2 accesses chromatin is unclear. We find that Jari...
ORGANISM(S): Mus musculus 
2010-01-01 | E-GEOD-19708 | biostudies-arrayexpress
GenomicsJarid2/Jumonji coordinates control of PRC2 enzymatic activity and target gene occupancy in pluripotent cells
We report on mechanism of interaction between PRC2 complex and Jarid2 and their role in pluripotent cells Examination of PRC2 genomic localization by analysis of Jarid2, Ezh2, Suz12 and Jarid1a occupancy
ORGANISM(S): Mus musculus 
2009-12-24 | E-GEOD-18776 | biostudies-arrayexpress
TranscriptomicsJarid2 regulates hematopoietic stem cell function by acting with Polycomb Repressive Complex 2
Polycomb Repressive Complex 2 (PRC2) has been shown to play a key role in hematopoietic stem and progenitor cell (HSPC) function. Analyses of mouse mutants harboring deletions of core components have implicated PRC2 in fine-tuning multiple pathways that instruct HSPC behavior, yet how PRC2 is target...
ORGANISM(S): Mus musculus 
2015-04-02 | E-GEOD-60808 | biostudies-arrayexpress
TranscriptomicsChIP-chip by array of mouse embryonic stem cells to analyze Jarid2 binding
Analysis of the binding of Jarid2 in mouse ES cells using a Flag tagged version of Jarid2 and a anti-Flag antibody.
ORGANISM(S): Mus musculus 
2010-04-13 | E-TABM-963 | biostudies-arrayexpress
TranscriptomicsNkx2.5 regulates Jarid2 during outflow tract morphogenesis
The transcription factor Nkx2.5 is required for specification of pharyngeal arch second heart field (SHF) progenitors that contribute to outflow tract (OFT) and right ventricle (RV) formation. Multiple sets of microarray data were analyzed to identify genes that are candidate targets of Nkx2.5 in th...
ORGANISM(S): Mus musculus 
2010-05-17 | E-GEOD-17936 | biostudies-arrayexpress
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