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TranscriptomicsRNA-seq experiment at four time points in HEK293 and hESC cells, assessing the time-resolved response on gene expression upon Wnt/β-catenin signaling activation
Wnt/β-catenin signaling is a highly organized biochemical cascade that triggers a gene expression program in the signal-receiving cell. The Wnt/β-catenin-driven transcriptional response is involved in virtually all cellular processes during development, homeostasis, and its deregulation causes human...
ORGANISM(S): Homo sapiens 
2022-09-30 | E-MTAB-12075 | biostudies-arrayexpress
TranscriptomicsATAC-seq experiment at four time points in HEK293 and hESC cells, assessing the time-resolved response on chromatin accessibility upon Wnt/β-catenin signaling activation
Wnt/β-catenin signaling is a highly organized biochemical cascade that triggers a gene expression program in the signal-receiving cell. The Wnt/β-catenin -driven transcriptional response is involved in virtually all cellular processes during development, homeostasis, and its deregulation causes huma...
ORGANISM(S): Homo sapiens 
2022-09-30 | E-MTAB-12076 | biostudies-arrayexpress
TranscriptomicsCUT&RUN experiment at four time points in HEK293T and hESC cells, assessing the time-resolved response of β-catenin genomic occupancy upon Wnt signaling activation
Wnt/β-catenin signaling is a highly organized biochemical cascade that triggers a gene expression program in the signal-receiving cell. The Wnt/β-catenin-driven transcriptional response is involved in virtually all cellular processes during development, homeostasis, and its deregulation causes human...
ORGANISM(S): Homo sapiens 
2022-09-30 | E-MTAB-12077 | biostudies-arrayexpress
TranscriptomicsSingle cell RNA-sequencing experiment of human embryonic stem cells (hESCs) upon Wnt stimulation treatment at three time points (4 hours, 24 hours and 3 days)
Wnt/b-catenin signalling is an evolutionarily conserved mechanism for cell-cell communication implicated in both developmental processes and diseases such as cancer. A main part of this signalling pathway is the stabilization and nuclear translocation of b-catenin, driving the transcriptional regula...
ORGANISM(S): Homo sapiens 
2023-02-23 | E-MTAB-12598 | biostudies-arrayexpress
TranscriptomicsCAGE-seq of human colon cancer cell line (HCT116) upon TBX3 overexpression
The Wnt/β-catenin signaling pathway plays crucial roles in nearly all parts of embryonic development and adult stem cell homeostasis. Its aberrant activation has been linked to many diseases such as developmental irregularities and various severe forms of cancer, with colorectal cancer (CRC) as a pr...
ORGANISM(S): Homo sapiens 
2024-01-01 | E-MTAB-13647 | biostudies-arrayexpress
TranscriptomicsExpression analysis in intestinal mucosa of genes under association peaks in celiac disease
Celiac disease is a chronic immune-mediated disorder with an important genetic component. To date, there are 57 independent association signals from 39 non-HLA loci, and a total of 66 candidate genes have been proposed. We aimed to scrutinize the functional implication of 45 of those genes by analyz...
ORGANISM(S): Homo sapiens 
2014-09-30 | E-GEOD-61849 | biostudies-arrayexpress
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