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UnknownSelective disruption of lipid peroxide homeostasis in intratumoral regulatory T cells by targeting FSP1 enhances cancer immunity.
A burgeoning approach to treating cancer is the pharmacological induction of ferroptotic cell death of tumor cells. However, the impact of disrupting antiferroptotic pathways in the broader tumor microenvironment (TME), such as in immune cells, is still undefined and may complicate treatments. Here,...
S-EPMC12829571 | biostudies-literature
UnknownGenetic ancestry proportion influences risk of adverse events from tuberculosis treatment in Brazil.
Tuberculosis (TB) treatment is highly effective, but response to therapy varies by geography and population subgroups. We assessed differences in TB treatment response in a representative and heterogeneous Brazilian population. We estimated genetic ancestry according to major genetic ancestry groups...
S-EPMC12774987 | biostudies-literature
UnknownAge of onset of amyotrophic lateral sclerosis is modulated by a locus on 1p34.1.
Amyotrophic lateral sclerosis (ALS) is the third most common adult-onset neurodegenerative disease. Individuals with ALS rapidly progress to paralysis and die from respiratory failure within 3 to 5 years after symptom onset. Epidemiological factors explain only a modest amount of the risk for ALS. H...
S-EPMC3839234 | biostudies-literature
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