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TranscriptomicsGlobal transcriptomic profiling of lactacystin-mediated neuronal death
Inhibition of proteasome degradation pathway has been implicated in neuronal cell death leading to neurodegenerative diseases such as ParkinsonM-bM-^@M-^Ys disease and AlzheimerM-bM-^@M-^Ys disease. Pharmacological proteasomal inhibitors such as lactacystin can induce apoptosis in cultured mouse co...
ORGANISM(S): Mus musculus 
2012-01-03 | E-GEOD-22465 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of blood samples from human patients with severe acute respiratory syndrome (SARS)
To understand the host response to this pathogen, we investigated the gene expression profiles of peripheral blood mononuclear cells (PBMCs) derived from SARS patients, and compared with healthy controls.
ORGANISM(S): Homo sapiens 
2007-08-04 | E-GEOD-1739 | biostudies-arrayexpress
TranscriptomicsGlobal transcriptomic profiling of ischemic/reperfusion injury in an in vivo Gpx1 -/- transgenic mouse model.
Glutathione peroxidase (Gpx) is a selenium-containing enzyme that catalyses the reduction of a variety of biological peroxides at the expense of reduced glutathione (GSH). Gpx1 is the most abundant isoform and its role has been implicated in neurodegenerative disorders such as ParkinsonM-bM-^@M-^Ys ...
ORGANISM(S): Mus musculus 
2011-01-10 | E-GEOD-23162 | biostudies-arrayexpress
TranscriptomicsCell cycle regulatory mechanisms in skeletal muscle cells
Genome wide gene expression analysis in G9a knockdown myoblasts Illumina WG-6 v2.0 arrays were hybridized with RNA from scrambled control and siG9a myoblasts to determine the gene expression profile murine skeletal myoblasts. All hybridizations were done in biological duplicates
ORGANISM(S): Mus musculus 
2016-07-21 | E-GEOD-70039 | biostudies-arrayexpress
TranscriptomicsGlobal transcriptomic profiling of nitric oxide-mediated neuronal death
Nitric oxide (NO) is implicated in the pathogenesis of various neuropathologies characterised by oxidative stress. NO has been reported to be involved in the exacerbation of oxidative stress by various mechanisms, including protein modification, genotoxic damage and elevated production of reactive o...
ORGANISM(S): Mus musculus 
2013-01-23 | E-GEOD-22087 | biostudies-arrayexpress
TranscriptomicsGlobal gene profiling comparison between hydrogen sulfide- and N-methyl-D-aspartate-induced neuronal deaths
Hydrogen sulfide (H2S), present in abundance in the mammalian brain, has recently been demonstrated to induce a dose- and time-dependent apoptotic-necrotic continuum in murine primary cortical neurons, which was successfully attenuated upon application of N-methyl-D-aspartate (NMDA) receptor antagon...
ORGANISM(S): Mus musculus 
2013-01-23 | E-GEOD-16035 | biostudies-arrayexpress
TranscriptomicsGlobal transcriptomic profiling of hypoxic ischemia in an in vivo neonatal mouse model: cortex
Hypoxia-ischemia (HI) brain damage is one of the most common causes of neonatal brain injuries, amidst other conditions such as intrauterine infection and perinatal cerebral hemorrhage (Bracci et al., 2006). HI, occurring during the perinatal period, severely affects brain integrity resulting in det...
ORGANISM(S): Mus musculus 
2013-12-31 | E-GEOD-23317 | biostudies-arrayexpress
TranscriptomicsGlobal transcriptomic profiling of hypoxic ischemia in an in vivo neonatal mouse model: Striatum
Hypoxia-ischemia (HI) brain damage is one of the most common causes of neonatal brain injuries, amidst other conditions such as intrauterine infection and perinatal cerebral hemorrhage (Bracci et al., 2006). HI, occurring during the perinatal period, severely affects brain integrity resulting in det...
ORGANISM(S): Mus musculus 
2013-12-31 | E-GEOD-23319 | biostudies-arrayexpress
TranscriptomicsTranscriptomic analysis of breast cancer
Transcriptomic analysis of fresh breast cancer tissue versus normal tissues. The Study comprising 45 Saudi-Arabian subjects was designed to take advantage of transcriptomics to prospectively explore the roles of lifestyle and genetic susceptibility in the occurrence of breast cancer. Total RNA isola...
ORGANISM(S): Homo sapiens 
2014-04-15 | E-GEOD-36295 | biostudies-arrayexpress
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