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GenomicsConserved DNA methylation patterns in healthy blood cells and extensive changes in leukemia measured by a new quantitative technique.
We describe a simple method, Digital Restriction Enzyme Analysis of Methylation (DREAM), based on sequential DNA digestion with a pair of methylation-blocked and methylation-tolerant neoschizomeric restriction enzymes SmaI/XmaI followed by end repair and ultra-deep sequencing. DREAM provides informa...
ORGANISM(S): Homo sapiens 
2012-11-08 | E-GEOD-39787 | biostudies-arrayexpress
GenomicsTET1 is a maintenance DNA demethylase that prevents methylation spreading in adult cells [MeDIP-Seq]
We report that full length TET1 (TET1-FL) overexpression fails to induce global DNA demethylation in HEK293T cells. The preferential binding of TET1-FL to hypomethylated CpG islands (CGIs) through its CXXC domain leads to its inhibited 5-hydroxymethylcytosine (5hmC) production as methylation level i...
ORGANISM(S): Homo sapiens 
2014-06-04 | E-GEOD-44036 | biostudies-arrayexpress
GenomicsTET1 is a maintenance DNA demethylase that prevents methylation spreading in adult cells [DREAM]
We report that full length TET1 (TET1-FL) overexpression fails to induce global DNA demethylation in HEK293T cells. The preferential binding of TET1-FL to hypomethylated CpG islands (CGIs) through its CXXC domain leads to its inhibited 5-hydroxymethylcytosine (5hmC) production as methylation level i...
ORGANISM(S): Homo sapiens 
2014-06-04 | E-GEOD-44038 | biostudies-arrayexpress
TranscriptomicsTET1 is a maintenance DNA demethylase that prevents methylation spreading in adult cells [cDNA microarray]
We report that full length TET1 (TET1-FL) overexpression fails to induce global DNA demethylation in HEK293T cells. The preferential binding of TET1-FL to hypomethylated CpG islands (CGIs) through its CXXC domain leads to its inhibited 5-hydroxymethylcytosine (5hmC) production as methylation level i...
ORGANISM(S): Homo sapiens 
2014-06-04 | E-GEOD-50016 | biostudies-arrayexpress
TranscriptomicsTET1 is a maintenance DNA demethylase that prevents methylation spreading in adult cells [RNA-seq]
We report that full length TET1 (TET1-FL) overexpression fails to induce global DNA demethylation in HEK293T cells. The preferential binding of TET1-FL to hypomethylated CpG islands (CGIs) through its CXXC domain leads to its inhibited 5-hydroxymethylcytosine (5hmC) production as methylation level i...
ORGANISM(S): Homo sapiens 
2014-06-04 | E-GEOD-49833 | biostudies-arrayexpress
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