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UnknownStructural basis for the selective inhibition of JNK1 by the scaffolding protein JIP1 and SP600125.
The c-jun N-terminal kinase (JNK) signaling pathway is regulated by JNK-interacting protein-1 (JIP1), which is a scaffolding protein assembling the components of the JNK cascade. Overexpression of JIP1 deactivates the JNK pathway selectively by cytoplasmic retention of JNK and thereby inhibits gene ...
S-EPMC419904 | biostudies-literature
UnknownClinical Outcomes and Response to Vericiguat According to Index Heart Failure Event: Insights From the VICTORIA Trial.

Importance

The period following heart failure hospitalization (HFH) is a vulnerable time with high rates of death or recurrent HFH.

Objective

To evaluate clinical characteristics, outcomes, and treatment response to vericiguat according to prespecified index event subgroups and time f...
S-EPMC7666431 | biostudies-literature
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