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TranscriptomicsPhysiological functions of the RORs in brown adipose tissue
To determine the physiological targets of the RORs in brown adipose tissue. Keywords: Nuclear receptors, RORs, adipose Gene expression analysis was conducted using Agilent whole mouse genome arrays (012694). The analysis was perfomed in duplicate, employing a fluor reversal. RNA was isolated from in...
ORGANISM(S): Mus musculus 
2008-12-18 | E-GEOD-9969 | biostudies-arrayexpress
TranscriptomicsIdentification of CD44 downstream target genes
CD44 expression has been shown to be enhanced in the liver and white adipose tissue (WAT) during obesity, suggesting a possible regulatory role for CD44 in metabolic syndrome. To study this hypothesis, we compared the gene expression profiles in liver and in WAT between WT and CD44 knockout (CD44KO)...
ORGANISM(S): Mus musculus 
2013-06-01 | E-GEOD-43104 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse liver from wild type (WT), RORalphasg/sg, RORgamma-/-, and double knockout animals reveals a regulatory role for RORalpha and RORgamma in Phase I and Phase II Metabolism
Retinoid-related orphan receptors RORalpha and RORgamma are both expressed in liver; however, their physiological functions have not yet been clearly defined. RORalpha1 and RORgamma1, but not RORalpha4, show an oscillatory pattern of expression during circadian rhythm. To obtain insight into the phy...
ORGANISM(S): Mus musculus 
2008-06-15 | E-GEOD-7564 | biostudies-arrayexpress
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